LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 13 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 3. - Dataset (ID:20250)

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Cell Small Molecule Small Mol Concentration Small Mol Conc Unit LJP Library Plate Timepoint Timepoint Unit Mean Total Cell Count Before Treatment Mean Total Cell Count After Treatment Mean Total Control Cell Count Mean Relative Cell Count Mean Normalized Growth Rate Inhibition Value
MDA-MB-231 Sirolimus
3.33
uM
LJP6
 72
hr
 1235 3311 4405 0.7516 0.7112
MDA-MB-231 Sirolimus
10
uM
LJP6
 72
hr
 1235 3274 4405 0.7430 0.7002
MDA-MB-231 ZSTK474
0.04
uM
LJP6
 72
hr
 1235 3680 4405 0.8361 0.8142
MDA-MB-231 ZSTK474
0.12
uM
LJP6
 72
hr
 1235 3522 4405 0.8000 0.7710
MDA-MB-231 ZSTK474
0.37
uM
LJP6
 72
hr
 1235 3300 4405 0.7503 0.7101
MDA-MB-231 ZSTK474
1.11
uM
LJP6
 72
hr
 1235 2846 4405 0.6472 0.5774
MDA-MB-231 ZSTK474
3.33
uM
LJP6
 72
hr
 1235 2374 4405 0.5395 0.4279
MDA-MB-231 ZSTK474
10
uM
LJP6
 72
hr
 1235 1901 4405 0.4313 0.2620
MDA-MB-231 BX-912
0.04
uM
LJP5
 72
hr
 1235 4297 4660 0.9201 0.9126
MDA-MB-231 BX-912
0.12
uM
LJP5
 72
hr
 1235 3850 4660 0.8257 0.8085
MDA-MB-231 BX-912
0.37
uM
LJP5
 72
hr
 1235 2132 4660 0.4572 0.3274
MDA-MB-231 BX-912
1.11
uM
LJP5
 72
hr
 1235 1614 4660 0.3456 0.1468
MDA-MB-231 BX-912
3.33
uM
LJP5
 72
hr
 1235 1343 4660 0.2874 0.0410
MDA-MB-231 BX-912
10
uM
LJP5
 72
hr
 1235 663 4660 0.1417 -0.2808
MDA-MB-231 Selumetinib
0.04
uM
LJP6
 72
hr
 1235 3888 4405 0.8832 0.8691
MDA-MB-231 Selumetinib
0.12
uM
LJP6
 72
hr
 1235 3641 4405 0.8273 0.8039
MDA-MB-231 Selumetinib
0.37
uM
LJP6
 72
hr
 1235 3086 4405 0.7006 0.6469
MDA-MB-231 Selumetinib
1.11
uM
LJP6
 72
hr
 1235 2705 4405 0.6153 0.5342
MDA-MB-231 Selumetinib
3.33
uM
LJP6
 72
hr
 1235 2332 4405 0.5296 0.4138
MDA-MB-231 Selumetinib
10
uM
LJP6
 72
hr
 1235 1577 4405 0.3581 0.1418
MDA-MB-231 MK2206
0.04
uM
LJP6
 72
hr
 1235 4100 4405 0.9310 0.9237
MDA-MB-231 MK2206
0.12
uM
LJP6
 72
hr
 1235 3998 4405 0.9080 0.8976
MDA-MB-231 MK2206
0.37
uM
LJP6
 72
hr
 1235 3881 4405 0.8809 0.8661
MDA-MB-231 MK2206
1.11
uM
LJP6
 72
hr
 1235 3694 4405 0.8395 0.8182
MDA-MB-231 MK2206
3.33
uM
LJP6
 72
hr
 1235 3454 4405 0.7849 0.7523