LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 13 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 3. - Dataset (ID:20250)

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Cell Small Molecule Small Mol Concentration Small Mol Conc Unit LJP Library Plate Timepoint Timepoint Unit Mean Total Cell Count Before Treatment Mean Total Cell Count After Treatment Mean Total Control Cell Count Mean Relative Cell Count Mean Normalized Growth Rate Inhibition Value
MCF 10A Fedratinib
1.11
uM
LJP5
 72
hr
 962 7838 10512 0.7457 0.8368
MCF 10A Fedratinib
3.33
uM
LJP5
 72
hr
 962 4226 10512 0.4026 0.5352
MCF 10A Fedratinib
10
uM
LJP5
 72
hr
 962 1123 10512 0.1069 0.0459
MCF 10A Trametinib
0.04
uM
LJP5
 72
hr
 962 1790 10512 0.1702 0.1960
MCF 10A Trametinib
0.12
uM
LJP5
 72
hr
 962 1803 10512 0.1716 0.1996
MCF 10A Trametinib
0.37
uM
LJP5
 72
hr
 962 1899 10512 0.1809 0.2179
MCF 10A Trametinib
1.11
uM
LJP5
 72
hr
 962 1832 10512 0.1746 0.2051
MCF 10A Trametinib
3.33
uM
LJP5
 72
hr
 962 1925 10512 0.1834 0.2221
MCF 10A Trametinib
10
uM
LJP5
 72
hr
 962 1979 10512 0.1884 0.2326
MCF 10A Omipalisib
0.04
uM
LJP6
 72
hr
 962 1009 10692 0.0944 0.0134
MCF 10A Omipalisib
0.12
uM
LJP6
 72
hr
 962 853 10692 0.0798 -0.0343
MCF 10A Omipalisib
0.37
uM
LJP6
 72
hr
 962 899 10692 0.0841 -0.0201
MCF 10A Omipalisib
1.11
uM
LJP6
 72
hr
 962 872 10692 0.0816 -0.0278
MCF 10A Omipalisib
3.33
uM
LJP6
 72
hr
 962 752 10692 0.0703 -0.0687
MCF 10A Omipalisib
10
uM
LJP6
 72
hr
 962 720 10692 0.0674 -0.0800
MCF 10A Buparlisib
0.04
uM
LJP5
 72
hr
 962 10708 10512 1.0185 1.0105
MCF 10A Buparlisib
0.12
uM
LJP5
 72
hr
 962 10235 10512 0.9736 0.9845
MCF 10A Buparlisib
0.37
uM
LJP5
 72
hr
 962 9430 10512 0.8972 0.9381
MCF 10A Buparlisib
1.11
uM
LJP5
 72
hr
 962 6073 10512 0.5777 0.7058
MCF 10A Buparlisib
3.33
uM
LJP5
 72
hr
 962 1383 10512 0.1316 0.1109
MCF 10A Buparlisib
10
uM
LJP5
 72
hr
 962 586 10512 0.0558 -0.1348
MCF 10A XL147
0.04
uM
LJP5
 72
hr
 962 10737 10512 1.0214 1.0123
MCF 10A XL147
0.12
uM
LJP5
 72
hr
 962 10032 10512 0.9544 0.9731
MCF 10A XL147
0.37
uM
LJP5
 72
hr
 962 9449 10512 0.8988 0.9390
MCF 10A XL147
1.11
uM
LJP5
 72
hr
 962 8797 10512 0.8369 0.8994