LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 13 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 3. - Dataset (ID:20250)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Normalized Growth Rate Inhibition Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10A | XMD11-85h | 0.12 | uM | LJP6 | 72 | hr | 962 | 10944 | 10692 | 1.0236 | 1.0135 |
| MCF 10A | Enzastaurin | 0.12 | uM | LJP5 | 72 | hr | 962 | 10762 | 10512 | 1.0237 | 1.0136 |
| MCF 10A | XMD11-85h | 0.04 | uM | LJP6 | 72 | hr | 962 | 10945 | 10692 | 1.0238 | 1.0134 |
| SK-BR-3 | PLX-4720 | 0.12 | uM | LJP5 | 72 | hr | 1401 | 4352 | 4245 | 1.0239 | 1.0280 |
| BT-20 | PHA-665752 | 0.04 | uM | LJP5 | 72 | hr | 1097 | 3938 | 3846 | 1.0242 | 1.0268 |
| SK-BR-3 | Vemurafenib | 0.12 | uM | LJP5 | 72 | hr | 1401 | 4341 | 4245 | 1.0247 | 1.0323 |
| BT-20 | Linifanib | 0.12 | uM | LJP6 | 72 | hr | 1097 | 3763 | 3673 | 1.0247 | 1.0279 |
| Hs 578T | Vemurafenib | 0.12 | uM | LJP5 | 72 | hr | 658 | 4031 | 3933 | 1.0248 | 1.0190 |
| MCF7 | Gefitinib | 0.04 | uM | LJP6 | 72 | hr | 1209 | 4112 | 4012 | 1.0253 | 1.0295 |
| MCF 10A | CP724714 | 0.04 | uM | LJP5 | 72 | hr | 962 | 10777 | 10512 | 1.0254 | 1.0146 |
| MCF 10A | Nintedanib | 0.04 | uM | LJP6 | 72 | hr | 962 | 10963 | 10692 | 1.0254 | 1.0145 |
| MCF7 | Erlotinib | 1.11 | uM | LJP5 | 72 | hr | 1209 | 4308 | 4203 | 1.0255 | 1.0285 |
| Hs 578T | PLX-4720 | 0.04 | uM | LJP5 | 72 | hr | 658 | 4035 | 3933 | 1.0257 | 1.0196 |
| SK-BR-3 | PD184352 | 0.04 | uM | LJP5 | 72 | hr | 1401 | 4357 | 4245 | 1.0259 | 1.0315 |
| MCF7 | Ruxolitinib | 0.04 | uM | LJP5 | 72 | hr | 1209 | 4326 | 4203 | 1.0260 | 1.0237 |
| MDA-MB-231 | OSI-027 | 0.04 | uM | LJP6 | 72 | hr | 1235 | 4518 | 4405 | 1.0262 | 1.0286 |
| SK-BR-3 | Ruxolitinib | 3.33 | uM | LJP5 | 72 | hr | 1401 | 4351 | 4245 | 1.0262 | 1.0335 |
| MCF 10A | NU7441 | 0.04 | uM | LJP5 | 72 | hr | 962 | 10789 | 10512 | 1.0262 | 1.0149 |
| Hs 578T | KIN001-043 | 0.12 | uM | LJP6 | 72 | hr | 658 | 3858 | 3761 | 1.0262 | 1.0206 |
| Hs 578T | Radicicol | 0.04 | uM | LJP6 | 72 | hr | 658 | 3861 | 3761 | 1.0265 | 1.0209 |
| SK-BR-3 | PD173074 | 0.37 | uM | LJP6 | 72 | hr | 1401 | 4279 | 4168 | 1.0268 | 1.0330 |
| MDA-MB-231 | CP724714 | 0.04 | uM | LJP5 | 72 | hr | 1235 | 4774 | 4660 | 1.0275 | 1.0295 |
| SK-BR-3 | PHA-665752 | 0.12 | uM | LJP5 | 72 | hr | 1401 | 4358 | 4245 | 1.0277 | 1.0358 |
| MCF7 | XL147 | 3.33 | uM | LJP5 | 72 | hr | 1209 | 4318 | 4203 | 1.0277 | 1.0308 |
| BT-20 | SB590885 | 0.37 | uM | LJP5 | 72 | hr | 1097 | 3951 | 3846 | 1.0281 | 1.0309 |