LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 13 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 3. - Dataset (ID:20250)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Normalized Growth Rate Inhibition Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-231 | Torin2 | 3.33 | uM | LJP5 | 72 | hr | 1235 | 428 | 4660 | 0.0890 | -0.5267 |
| MDA-MB-231 | AT-7519 | 1.11 | uM | LJP6 | 72 | hr | 1235 | 324 | 4405 | 0.0730 | -0.5262 |
| MDA-MB-231 | Geldanamycin | 10 | uM | LJP6 | 72 | hr | 1235 | 334 | 4405 | 0.0750 | -0.5239 |
| Hs 578T | AZD8055 | 10 | uM | LJP6 | 72 | hr | 658 | 103 | 3761 | 0.0276 | -0.5223 |
| SK-BR-3 | AZD8055 | 10 | uM | LJP6 | 72 | hr | 1401 | 443 | 4168 | 0.1063 | -0.5192 |
| MDA-MB-231 | CGP60474 | 10 | uM | LJP6 | 72 | hr | 1235 | 340 | 4405 | 0.0765 | -0.5175 |
| MCF7 | JNK-9L | 3.33 | uM | LJP6 | 72 | hr | 1209 | 353 | 4012 | 0.0879 | -0.5100 |
| MDA-MB-231 | CGP60474 | 1.11 | uM | LJP6 | 72 | hr | 1235 | 344 | 4405 | 0.0776 | -0.5060 |
| MDA-MB-231 | A443654 | 10 | uM | LJP6 | 72 | hr | 1235 | 344 | 4405 | 0.0782 | -0.5024 |
| BT-20 | Celastrol | 10 | uM | LJP6 | 72 | hr | 1097 | 333 | 3673 | 0.0907 | -0.4958 |
| SK-BR-3 | AT-7519 | 10 | uM | LJP6 | 72 | hr | 1401 | 486 | 4168 | 0.1167 | -0.4930 |
| MDA-MB-231 | AZD 5438 | 10 | uM | LJP6 | 72 | hr | 1235 | 361 | 4405 | 0.0821 | -0.4892 |
| MCF7 | AZD8055 | 10 | uM | LJP6 | 72 | hr | 1209 | 388 | 4012 | 0.0968 | -0.4820 |
| MDA-MB-231 | LDN-193189 | 3.33 | uM | LJP5 | 72 | hr | 1235 | 357 | 4660 | 0.0768 | -0.4791 |
| Hs 578T | SB590885 | 10 | uM | LJP5 | 72 | hr | 658 | 125 | 3933 | 0.0320 | -0.4740 |
| SK-BR-3 | HG-6-64-01 | 10 | uM | LJP6 | 72 | hr | 1401 | 516 | 4168 | 0.1238 | -0.4732 |
| MDA-MB-231 | NVP-TAE684 | 10 | uM | LJP6 | 72 | hr | 1235 | 382 | 4405 | 0.0872 | -0.4731 |
| MCF7 | A443654 | 10 | uM | LJP6 | 72 | hr | 1209 | 403 | 4012 | 0.1003 | -0.4714 |
| BT-20 | LDN-193189 | 3.33 | uM | LJP5 | 72 | hr | 1097 | 357 | 3846 | 0.0923 | -0.4691 |
| BT-20 | GSK1059615 | 10 | uM | LJP5 | 72 | hr | 1097 | 354 | 3846 | 0.0918 | -0.4691 |
| MDA-MB-231 | PHA-793887 | 10 | uM | LJP6 | 72 | hr | 1235 | 398 | 4405 | 0.0905 | -0.4615 |
| MDA-MB-231 | Y39983 | 10 | uM | LJP6 | 72 | hr | 1235 | 403 | 4405 | 0.0917 | -0.4576 |
| SK-BR-3 | LDN-193189 | 10 | uM | LJP5 | 72 | hr | 1401 | 557 | 4245 | 0.1286 | -0.4568 |
| MDA-MB-231 | BMS345541 | 10 | uM | LJP6 | 72 | hr | 1235 | 408 | 4405 | 0.0926 | -0.4547 |
| MDA-MB-231 | AZD7762 | 10 | uM | LJP6 | 72 | hr | 1235 | 409 | 4405 | 0.0926 | -0.4545 |