LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 13 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 3. - Dataset (ID:20250)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Normalized Growth Rate Inhibition Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | LDN-193189 | 0.04 | uM | LJP5 | 72 | hr | 1401 | 4952 | 4245 | 1.1690 | 1.2085 |
| SK-BR-3 | XL147 | 1.11 | uM | LJP5 | 72 | hr | 1401 | 4944 | 4245 | 1.1686 | 1.2092 |
| MDA-MB-231 | PD173074 | 0.37 | uM | LJP6 | 72 | hr | 1235 | 5078 | 4405 | 1.1552 | 1.1644 |
| MDA-MB-231 | Celastrol | 0.04 | uM | LJP6 | 72 | hr | 1235 | 5069 | 4405 | 1.1523 | 1.1611 |
| SK-BR-3 | CP466722 | 0.04 | uM | LJP5 | 72 | hr | 1401 | 4863 | 4245 | 1.1519 | 1.1903 |
| SK-BR-3 | TWS119 | 0.04 | uM | LJP5 | 72 | hr | 1401 | 4829 | 4245 | 1.1428 | 1.1791 |
| SK-BR-3 | XL147 | 3.33 | uM | LJP5 | 72 | hr | 1401 | 4818 | 4245 | 1.1412 | 1.1776 |
| SK-BR-3 | XL147 | 0.12 | uM | LJP5 | 72 | hr | 1401 | 4821 | 4245 | 1.1409 | 1.1763 |
| SK-BR-3 | Nilotinib | 1.11 | uM | LJP5 | 72 | hr | 1401 | 4831 | 4245 | 1.1381 | 1.1695 |
| SK-BR-3 | SB590885 | 0.04 | uM | LJP5 | 72 | hr | 1401 | 4804 | 4245 | 1.1362 | 1.1710 |
| SK-BR-3 | YM 201636 | 0.04 | uM | LJP5 | 72 | hr | 1401 | 4814 | 4245 | 1.1359 | 1.1686 |
| SK-BR-3 | Nilotinib | 0.37 | uM | LJP5 | 72 | hr | 1401 | 4822 | 4245 | 1.1351 | 1.1650 |
| SK-BR-3 | Linifanib | 0.37 | uM | LJP6 | 72 | hr | 1401 | 4681 | 4168 | 1.1232 | 1.1535 |
| SK-BR-3 | WH-4-025 | 0.04 | uM | LJP5 | 72 | hr | 1401 | 4737 | 4245 | 1.1201 | 1.1513 |
| BT-20 | Enzastaurin | 10 | uM | LJP5 | 72 | hr | 1097 | 4311 | 3846 | 1.1195 | 1.1266 |
| MDA-MB-231 | PD173074 | 1.11 | uM | LJP6 | 72 | hr | 1235 | 4916 | 4405 | 1.1188 | 1.1268 |
| BT-20 | XL147 | 0.04 | uM | LJP5 | 72 | hr | 1097 | 4302 | 3846 | 1.1181 | 1.1267 |
| SK-BR-3 | Nilotinib | 3.33 | uM | LJP5 | 72 | hr | 1401 | 4741 | 4245 | 1.1176 | 1.1453 |
| BT-20 | XL147 | 0.12 | uM | LJP5 | 72 | hr | 1097 | 4280 | 3846 | 1.1141 | 1.1232 |
| SK-BR-3 | Nilotinib | 0.04 | uM | LJP5 | 72 | hr | 1401 | 4725 | 4245 | 1.1140 | 1.1414 |
| SK-BR-3 | SB590885 | 1.11 | uM | LJP5 | 72 | hr | 1401 | 4714 | 4245 | 1.1121 | 1.1397 |
| SK-BR-3 | XL147 | 0.37 | uM | LJP5 | 72 | hr | 1401 | 4686 | 4245 | 1.1119 | 1.1421 |
| Hs 578T | SB590885 | 0.04 | uM | LJP5 | 72 | hr | 658 | 4370 | 3933 | 1.1111 | 1.0833 |
| SK-BR-3 | Nilotinib | 0.12 | uM | LJP5 | 72 | hr | 1401 | 4727 | 4245 | 1.1110 | 1.1335 |
| MDA-MB-231 | Enzastaurin | 10 | uM | LJP5 | 72 | hr | 1235 | 5177 | 4660 | 1.1109 | 1.1130 |