LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 13 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 3. - Dataset (ID:20250)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Normalized Growth Rate Inhibition Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10A | AZD8055 | 10 | uM | LJP6 | 72 | hr | 962 | 57 | 10692 | 0.0053 | -0.5572 |
| Hs 578T | Mitoxantrone | 10 | uM | LJP5 | 72 | hr | 658 | 25 | 3933 | 0.0064 | -0.7202 |
| Hs 578T | Mitoxantrone | 10 | uM | LJP6 | 72 | hr | 658 | 35 | 3761 | 0.0093 | -0.6912 |
| MCF 10A | LDN-193189 | 10 | uM | LJP5 | 72 | hr | 962 | 136 | 10512 | 0.0130 | -0.4374 |
| Hs 578T | PHA-665752 | 10 | uM | LJP5 | 72 | hr | 658 | 53 | 3933 | 0.0136 | -0.6240 |
| MCF 10A | A443654 | 10 | uM | LJP6 | 72 | hr | 962 | 173 | 10692 | 0.0162 | -0.3911 |
| MCF7 | Mitoxantrone | 10 | uM | LJP6 | 72 | hr | 1209 | 70 | 4012 | 0.0175 | -0.8076 |
| MCF 10A | WZ3105 | 10 | uM | LJP5 | 72 | hr | 962 | 185 | 10512 | 0.0176 | -0.3840 |
| MCF 10A | AT-7519 | 3.33 | uM | LJP6 | 72 | hr | 962 | 194 | 10692 | 0.0181 | -0.3695 |
| MCF 10A | AT-7519 | 10 | uM | LJP6 | 72 | hr | 962 | 195 | 10692 | 0.0183 | -0.3686 |
| MDA-MB-231 | Mitoxantrone | 10 | uM | LJP5 | 72 | hr | 1235 | 86 | 4660 | 0.0186 | -0.7515 |
| MCF 10A | Alvocidib | 0.37 | uM | LJP6 | 72 | hr | 962 | 200 | 10692 | 0.0187 | -0.3636 |
| MCF 10A | Alvocidib | 3.33 | uM | LJP6 | 72 | hr | 962 | 204 | 10692 | 0.0191 | -0.3608 |
| MCF 10A | Canertinib | 10 | uM | LJP6 | 72 | hr | 962 | 208 | 10692 | 0.0195 | -0.3567 |
| MCF 10A | Alvocidib | 1.11 | uM | LJP6 | 72 | hr | 962 | 212 | 10692 | 0.0198 | -0.3536 |
| MCF 10A | WZ3105 | 3.33 | uM | LJP5 | 72 | hr | 962 | 211 | 10512 | 0.0201 | -0.3563 |
| MCF7 | Mitoxantrone | 10 | uM | LJP5 | 72 | hr | 1209 | 89 | 4203 | 0.0213 | -0.7655 |
| SK-BR-3 | Mitoxantrone | 10 | uM | LJP5 | 72 | hr | 1401 | 91 | 4245 | 0.0217 | -0.8201 |
| MCF 10A | CGP60474 | 1.11 | uM | LJP6 | 72 | hr | 962 | 236 | 10692 | 0.0221 | -0.3323 |
| MCF 10A | CGP60474 | 3.33 | uM | LJP6 | 72 | hr | 962 | 238 | 10692 | 0.0223 | -0.3328 |
| MCF 10A | CGP60474 | 1.11 | uM | LJP5 | 72 | hr | 962 | 245 | 10512 | 0.0233 | -0.3280 |
| MCF 10A | Alvocidib | 10 | uM | LJP6 | 72 | hr | 962 | 252 | 10692 | 0.0236 | -0.3198 |
| MCF 10A | CGP60474 | 0.12 | uM | LJP6 | 72 | hr | 962 | 253 | 10692 | 0.0237 | -0.3195 |
| MCF 10A | WZ3105 | 1.11 | uM | LJP5 | 72 | hr | 962 | 254 | 10512 | 0.0242 | -0.3207 |
| MCF 10A | AZD 5438 | 3.33 | uM | LJP6 | 72 | hr | 962 | 260 | 10692 | 0.0244 | -0.3138 |