LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 13 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 3. - Dataset (ID:20250)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Normalized Growth Rate Inhibition Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | XL147 | 0.04 | uM | LJP5 | 72 | hr | 1401 | 4661 | 4245 | 1.0997 | 1.1246 |
| BT-20 | XL147 | 0.12 | uM | LJP5 | 72 | hr | 1097 | 4280 | 3846 | 1.1141 | 1.1232 |
| SK-BR-3 | CP466722 | 0.37 | uM | LJP5 | 72 | hr | 1401 | 4613 | 4245 | 1.0928 | 1.1181 |
| MDA-MB-231 | Linifanib | 1.11 | uM | LJP6 | 72 | hr | 1235 | 4890 | 4405 | 1.1105 | 1.1181 |
| SK-BR-3 | Linifanib | 0.04 | uM | LJP6 | 72 | hr | 1401 | 4563 | 4168 | 1.0943 | 1.1173 |
| SK-BR-3 | Imatinib | 0.12 | uM | LJP6 | 72 | hr | 1401 | 4559 | 4168 | 1.0934 | 1.1167 |
| BT-20 | Enzastaurin | 3.33 | uM | LJP5 | 72 | hr | 1097 | 4264 | 3846 | 1.1084 | 1.1156 |
| MDA-MB-231 | Enzastaurin | 10 | uM | LJP5 | 72 | hr | 1235 | 5177 | 4660 | 1.1109 | 1.1130 |
| BT-20 | PD173074 | 3.33 | uM | LJP6 | 72 | hr | 1097 | 4036 | 3673 | 1.0993 | 1.1117 |
| SK-BR-3 | Foretinib | 0.04 | uM | LJP5 | 72 | hr | 1401 | 4620 | 4245 | 1.0893 | 1.1112 |
| BT-20 | Withaferin A | 0.12 | uM | LJP5 | 72 | hr | 1097 | 4236 | 3846 | 1.1019 | 1.1104 |
| SK-BR-3 | Enzastaurin | 0.37 | uM | LJP5 | 72 | hr | 1401 | 4602 | 4245 | 1.0878 | 1.1104 |
| SK-BR-3 | R406 | 3.33 | uM | LJP6 | 72 | hr | 1401 | 4528 | 4168 | 1.0876 | 1.1099 |
| MCF7 | Y39983 | 0.04 | uM | LJP6 | 72 | hr | 1209 | 4386 | 4012 | 1.0946 | 1.1082 |
| MDA-MB-231 | Nintedanib | 0.04 | uM | LJP6 | 72 | hr | 1235 | 4845 | 4405 | 1.1005 | 1.1078 |
| SK-BR-3 | YM 201636 | 0.37 | uM | LJP5 | 72 | hr | 1401 | 4604 | 4245 | 1.0849 | 1.1056 |
| SK-BR-3 | Saracatinib | 0.12 | uM | LJP6 | 72 | hr | 1401 | 4520 | 4168 | 1.0838 | 1.1042 |
| SK-BR-3 | SB590885 | 0.12 | uM | LJP5 | 72 | hr | 1401 | 4604 | 4245 | 1.0840 | 1.1029 |
| SK-BR-3 | HG-6-64-01 | 0.04 | uM | LJP6 | 72 | hr | 1401 | 4507 | 4168 | 1.0819 | 1.1028 |
| SK-BR-3 | Enzastaurin | 3.33 | uM | LJP5 | 72 | hr | 1401 | 4584 | 4245 | 1.0808 | 1.1009 |
| SK-BR-3 | Imatinib | 0.37 | uM | LJP6 | 72 | hr | 1401 | 4499 | 4168 | 1.0796 | 1.0996 |
| BT-20 | PD173074 | 0.12 | uM | LJP6 | 72 | hr | 1097 | 3999 | 3673 | 1.0882 | 1.0989 |
| SK-BR-3 | PD184352 | 0.12 | uM | LJP5 | 72 | hr | 1401 | 4570 | 4245 | 1.0784 | 1.0989 |
| BT-20 | Celastrol | 0.04 | uM | LJP6 | 72 | hr | 1097 | 3972 | 3673 | 1.0821 | 1.0926 |
| SK-BR-3 | Vemurafenib | 0.04 | uM | LJP5 | 72 | hr | 1401 | 4553 | 4245 | 1.0737 | 1.0925 |