LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 12 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 2. - Dataset (ID:20249)

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Cell Small Molecule Small Mol Concentration Small Mol Conc Unit LJP Library Plate Timepoint Timepoint Unit Mean Total Cell Count Before Treatment Mean Total Cell Count After Treatment Mean Total Control Cell Count Mean Relative Cell Count Mean Normalized Growth Rate Inhibition Value
MDA-MB-231 PI103
0.37
uM
LJP6
 72
hr
 1311 3001 4935 0.6082 0.5418
MDA-MB-231 PI103
1.11
uM
LJP6
 72
hr
 1311 2447 4935 0.4960 0.3856
MDA-MB-231 PI103
3.33
uM
LJP6
 72
hr
 1311 1907 4935 0.3864 0.2160
MDA-MB-231 PI103
10
uM
LJP6
 72
hr
 1311 1382 4935 0.2802 0.0278
MDA-MB-231 Dovitinib
0.04
uM
LJP5
 72
hr
 1311 4858 5079 0.9562 0.9544
MDA-MB-231 Dovitinib
0.12
uM
LJP5
 72
hr
 1311 4826 5079 0.9501 0.9482
MDA-MB-231 Dovitinib
0.37
uM
LJP5
 72
hr
 1311 3488 5079 0.6868 0.6500
MDA-MB-231 Dovitinib
1.11
uM
LJP5
 72
hr
 1311 3204 5079 0.6308 0.5792
MDA-MB-231 Dovitinib
3.33
uM
LJP5
 72
hr
 1311 2456 5079 0.4836 0.3786
MDA-MB-231 Dovitinib
10
uM
LJP5
 72
hr
 1311 2027 5079 0.3991 0.2496
MDA-MB-231 GSK 690693
0.04
uM
LJP5
 72
hr
 1311 4763 5079 0.9380 0.9354
MDA-MB-231 GSK 690693
0.12
uM
LJP5
 72
hr
 1311 4722 5079 0.9298 0.9269
MDA-MB-231 GSK 690693
0.37
uM
LJP5
 72
hr
 1311 4632 5079 0.9120 0.9077
MDA-MB-231 GSK 690693
1.11
uM
LJP5
 72
hr
 1311 4664 5079 0.9185 0.9147
MDA-MB-231 GSK 690693
3.33
uM
LJP5
 72
hr
 1311 4949 5079 0.9745 0.9737
MDA-MB-231 GSK 690693
10
uM
LJP5
 72
hr
 1311 4646 5079 0.9148 0.9107
MDA-MB-231 SNS-032
0.04
uM
LJP6
 72
hr
 1311 2350 4935 0.4764 0.3565
MDA-MB-231 SNS-032
0.12
uM
LJP6
 72
hr
 1311 813 4935 0.1648 -0.2214
MDA-MB-231 SNS-032
0.37
uM
LJP6
 72
hr
 1311 723 4935 0.1467 -0.2674
MDA-MB-231 SNS-032
1.11
uM
LJP6
 72
hr
 1311 763 4935 0.1547 -0.2469
MDA-MB-231 SNS-032
3.33
uM
LJP6
 72
hr
 1311 804 4935 0.1630 -0.2258
MDA-MB-231 SNS-032
10
uM
LJP6
 72
hr
 1311 818 4935 0.1658 -0.2191
MDA-MB-231 Afatinib
0.04
uM
LJP6
 72
hr
 1311 4376 4935 0.8868 0.8782
MDA-MB-231 Afatinib
0.12
uM
LJP6
 72
hr
 1311 4369 4935 0.8852 0.8764
MDA-MB-231 Afatinib
0.37
uM
LJP6
 72
hr
 1311 3658 4935 0.7410 0.7094