LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 12 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 2. - Dataset (ID:20249)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Normalized Growth Rate Inhibition Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-231 | Sirolimus | 3.33 | uM | LJP6 | 72 | hr | 1311 | 4259 | 4935 | 0.8633 | 0.8518 |
| MDA-MB-231 | Sirolimus | 10 | uM | LJP6 | 72 | hr | 1311 | 4299 | 4935 | 0.8712 | 0.8608 |
| MDA-MB-231 | ZSTK474 | 0.04 | uM | LJP6 | 72 | hr | 1311 | 4440 | 4935 | 0.9000 | 0.8926 |
| MDA-MB-231 | ZSTK474 | 0.12 | uM | LJP6 | 72 | hr | 1311 | 4180 | 4935 | 0.8471 | 0.8332 |
| MDA-MB-231 | ZSTK474 | 0.37 | uM | LJP6 | 72 | hr | 1311 | 3694 | 4935 | 0.7486 | 0.7179 |
| MDA-MB-231 | ZSTK474 | 1.11 | uM | LJP6 | 72 | hr | 1311 | 3595 | 4935 | 0.7285 | 0.6946 |
| MDA-MB-231 | ZSTK474 | 3.33 | uM | LJP6 | 72 | hr | 1311 | 2945 | 4935 | 0.5971 | 0.5264 |
| MDA-MB-231 | ZSTK474 | 10 | uM | LJP6 | 72 | hr | 1311 | 2522 | 4935 | 0.5113 | 0.4078 |
| MDA-MB-231 | BX-912 | 0.04 | uM | LJP5 | 72 | hr | 1311 | 4614 | 5079 | 0.9086 | 0.9042 |
| MDA-MB-231 | BX-912 | 0.12 | uM | LJP5 | 72 | hr | 1311 | 4923 | 5079 | 0.9693 | 0.9683 |
| MDA-MB-231 | BX-912 | 0.37 | uM | LJP5 | 72 | hr | 1311 | 4567 | 5079 | 0.8991 | 0.8940 |
| MDA-MB-231 | BX-912 | 1.11 | uM | LJP5 | 72 | hr | 1311 | 3259 | 5079 | 0.6415 | 0.5931 |
| MDA-MB-231 | BX-912 | 3.33 | uM | LJP5 | 72 | hr | 1311 | 2012 | 5079 | 0.3963 | 0.2443 |
| MDA-MB-231 | BX-912 | 10 | uM | LJP5 | 72 | hr | 1311 | 1207 | 5079 | 0.2376 | -0.0419 |
| MDA-MB-231 | Selumetinib | 0.04 | uM | LJP6 | 72 | hr | 1311 | 3862 | 4935 | 0.7827 | 0.7592 |
| MDA-MB-231 | Selumetinib | 0.12 | uM | LJP6 | 72 | hr | 1311 | 3266 | 4935 | 0.6621 | 0.6116 |
| MDA-MB-231 | Selumetinib | 0.37 | uM | LJP6 | 72 | hr | 1311 | 2820 | 4935 | 0.5715 | 0.4924 |
| MDA-MB-231 | Selumetinib | 1.11 | uM | LJP6 | 72 | hr | 1311 | 2510 | 4935 | 0.5087 | 0.4041 |
| MDA-MB-231 | Selumetinib | 3.33 | uM | LJP6 | 72 | hr | 1311 | 2116 | 4935 | 0.4288 | 0.2841 |
| MDA-MB-231 | Selumetinib | 10 | uM | LJP6 | 72 | hr | 1311 | 1752 | 4935 | 0.3551 | 0.1635 |
| MDA-MB-231 | MK2206 | 0.04 | uM | LJP6 | 72 | hr | 1311 | 4932 | 4935 | 0.9995 | 0.9995 |
| MDA-MB-231 | MK2206 | 0.12 | uM | LJP6 | 72 | hr | 1311 | 4681 | 4935 | 0.9487 | 0.9457 |
| MDA-MB-231 | MK2206 | 0.37 | uM | LJP6 | 72 | hr | 1311 | 4166 | 4935 | 0.8444 | 0.8306 |
| MDA-MB-231 | MK2206 | 1.11 | uM | LJP6 | 72 | hr | 1311 | 4294 | 4935 | 0.8700 | 0.8593 |
| MDA-MB-231 | MK2206 | 3.33 | uM | LJP6 | 72 | hr | 1311 | 4082 | 4935 | 0.8270 | 0.8105 |