LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 12 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 2. - Dataset (ID:20249)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Normalized Growth Rate Inhibition Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | Crizotinib | 1.11 | uM | LJP5 | 72 | hr | 2543 | 4743 | 5752 | 0.8246 | 0.6972 |
| SK-BR-3 | Crizotinib | 3.33 | uM | LJP5 | 72 | hr | 2543 | 3902 | 5752 | 0.6784 | 0.4384 |
| SK-BR-3 | Crizotinib | 10 | uM | LJP5 | 72 | hr | 2543 | 1777 | 5752 | 0.3090 | -0.2625 |
| SK-BR-3 | BMS345541 | 0.04 | uM | LJP6 | 72 | hr | 2543 | 5441 | 5418 | 1.0051 | 1.0112 |
| SK-BR-3 | BMS345541 | 0.12 | uM | LJP6 | 72 | hr | 2543 | 5210 | 5418 | 0.9615 | 0.9289 |
| SK-BR-3 | BMS345541 | 0.37 | uM | LJP6 | 72 | hr | 2543 | 5050 | 5418 | 0.9328 | 0.8778 |
| SK-BR-3 | BMS345541 | 1.11 | uM | LJP6 | 72 | hr | 2543 | 4184 | 5418 | 0.7727 | 0.5792 |
| SK-BR-3 | BMS345541 | 3.33 | uM | LJP6 | 72 | hr | 2543 | 2736 | 5418 | 0.5051 | 0.0688 |
| SK-BR-3 | BMS345541 | 10 | uM | LJP6 | 72 | hr | 2543 | 933 | 5418 | 0.1724 | -0.6013 |
| SK-BR-3 | KIN001-043 | 0.04 | uM | LJP6 | 72 | hr | 2543 | 5261 | 5418 | 0.9716 | 0.9494 |
| SK-BR-3 | KIN001-043 | 0.12 | uM | LJP6 | 72 | hr | 2543 | 5207 | 5418 | 0.9620 | 0.9320 |
| SK-BR-3 | KIN001-043 | 0.37 | uM | LJP6 | 72 | hr | 2543 | 4779 | 5418 | 0.8822 | 0.7831 |
| SK-BR-3 | KIN001-043 | 1.11 | uM | LJP6 | 72 | hr | 2543 | 4273 | 5418 | 0.7888 | 0.6089 |
| SK-BR-3 | KIN001-043 | 3.33 | uM | LJP6 | 72 | hr | 2543 | 4206 | 5418 | 0.7761 | 0.5845 |
| SK-BR-3 | KIN001-043 | 10 | uM | LJP6 | 72 | hr | 2543 | 2923 | 5418 | 0.5400 | 0.1367 |
| SK-BR-3 | Saracatinib | 0.04 | uM | LJP6 | 72 | hr | 2543 | 5777 | 5418 | 1.0665 | 1.1220 |
| SK-BR-3 | Saracatinib | 0.12 | uM | LJP6 | 72 | hr | 2543 | 5463 | 5418 | 1.0088 | 1.0171 |
| SK-BR-3 | Saracatinib | 0.37 | uM | LJP6 | 72 | hr | 2543 | 5274 | 5418 | 0.9737 | 0.9522 |
| SK-BR-3 | Saracatinib | 1.11 | uM | LJP6 | 72 | hr | 2543 | 4967 | 5418 | 0.9169 | 0.8468 |
| SK-BR-3 | Saracatinib | 3.33 | uM | LJP6 | 72 | hr | 2543 | 4591 | 5418 | 0.8476 | 0.7188 |
| SK-BR-3 | Saracatinib | 10 | uM | LJP6 | 72 | hr | 2543 | 2760 | 5418 | 0.5096 | 0.0776 |
| SK-BR-3 | Sigma A6730 | 0.04 | uM | LJP5 | 72 | hr | 2543 | 4404 | 5752 | 0.7656 | 0.5932 |
| SK-BR-3 | Sigma A6730 | 0.12 | uM | LJP5 | 72 | hr | 2543 | 4904 | 5752 | 0.8526 | 0.7467 |
| SK-BR-3 | Sigma A6730 | 0.37 | uM | LJP5 | 72 | hr | 2543 | 4912 | 5752 | 0.8539 | 0.7490 |
| SK-BR-3 | Sigma A6730 | 1.11 | uM | LJP5 | 72 | hr | 2543 | 4238 | 5752 | 0.7369 | 0.5431 |