LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 12 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 2. - Dataset (ID:20249)

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Cell Small Molecule Small Mol Concentration Small Mol Conc Unit LJP Library Plate Timepoint Timepoint Unit Mean Total Cell Count Before Treatment Mean Total Cell Count After Treatment Mean Total Control Cell Count Mean Relative Cell Count Mean Normalized Growth Rate Inhibition Value
MCF 10A Fedratinib
1.11
uM
LJP5
 72
hr
 1694 9912 11103 0.8928 0.9180
MCF 10A Fedratinib
3.33
uM
LJP5
 72
hr
 1694 7024 11103 0.6325 0.6889
MCF 10A Fedratinib
10
uM
LJP5
 72
hr
 1694 2149 11103 0.1936 0.0906
MCF 10A Trametinib
0.04
uM
LJP5
 72
hr
 1694 2756 11103 0.2482 0.1961
MCF 10A Trametinib
0.12
uM
LJP5
 72
hr
 1694 2983 11103 0.2688 0.2317
MCF 10A Trametinib
0.37
uM
LJP5
 72
hr
 1694 3044 11103 0.2743 0.2407
MCF 10A Trametinib
1.11
uM
LJP5
 72
hr
 1694 3255 11103 0.2932 0.2722
MCF 10A Trametinib
3.33
uM
LJP5
 72
hr
 1694 3133 11103 0.2822 0.2543
MCF 10A Trametinib
10
uM
LJP5
 72
hr
 1694 3367 11103 0.3032 0.2879
MCF 10A Omipalisib
0.04
uM
LJP6
 72
hr
 1694 2233 11217 0.1990 0.1064
MCF 10A Omipalisib
0.12
uM
LJP6
 72
hr
 1694 1837 11217 0.1637 0.0296
MCF 10A Omipalisib
0.37
uM
LJP6
 72
hr
 1694 1730 11217 0.1543 0.0076
MCF 10A Omipalisib
1.11
uM
LJP6
 72
hr
 1694 1636 11217 0.1458 -0.0139
MCF 10A Omipalisib
3.33
uM
LJP6
 72
hr
 1694 1499 11217 0.1337 -0.0455
MCF 10A Omipalisib
10
uM
LJP6
 72
hr
 1694 925 11217 0.0825 -0.1994
MCF 10A Buparlisib
0.04
uM
LJP5
 72
hr
 1694 11151 11103 1.0043 1.0031
MCF 10A Buparlisib
0.12
uM
LJP5
 72
hr
 1694 10775 11103 0.9704 0.9780
MCF 10A Buparlisib
0.37
uM
LJP5
 72
hr
 1694 9711 11103 0.8746 0.9035
MCF 10A Buparlisib
1.11
uM
LJP5
 72
hr
 1694 5137 11103 0.4626 0.5047
MCF 10A Buparlisib
3.33
uM
LJP5
 72
hr
 1694 1798 11103 0.1620 0.0218
MCF 10A Buparlisib
10
uM
LJP5
 72
hr
 1694 615 11103 0.0554 -0.3121
MCF 10A XL147
0.04
uM
LJP5
 72
hr
 1694 11313 11103 1.0189 1.0138
MCF 10A XL147
0.12
uM
LJP5
 72
hr
 1694 10818 11103 0.9743 0.9809
MCF 10A XL147
0.37
uM
LJP5
 72
hr
 1694 10465 11103 0.9425 0.9568
MCF 10A XL147
1.11
uM
LJP5
 72
hr
 1694 10115 11103 0.9110 0.9325