LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 12 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 2. - Dataset (ID:20249)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Normalized Growth Rate Inhibition Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-231 | Canertinib | 0.04 | uM | LJP6 | 72 | hr | 1311 | 5102 | 4935 | 1.0342 | 1.0355 |
| BT-20 | Buparlisib | 0.04 | uM | LJP5 | 72 | hr | 1334 | 4150 | 4033 | 1.0287 | 1.0355 |
| Hs 578T | Celastrol | 0.12 | uM | LJP6 | 72 | hr | 765 | 3214 | 3101 | 1.0362 | 1.0352 |
| MDA-MB-231 | Pelitinib | 0.12 | uM | LJP5 | 72 | hr | 1311 | 5253 | 5079 | 1.0345 | 1.0350 |
| BT-20 | OSI-027 | 0.04 | uM | LJP6 | 72 | hr | 1334 | 4032 | 3925 | 1.0276 | 1.0348 |
| SK-BR-3 | R406 | 3.33 | uM | LJP6 | 72 | hr | 2543 | 5508 | 5418 | 1.0177 | 1.0347 |
| MDA-MB-231 | PD173074 | 0.12 | uM | LJP6 | 72 | hr | 1311 | 5103 | 4935 | 1.0337 | 1.0344 |
| BT-20 | YM 201636 | 0.12 | uM | LJP5 | 72 | hr | 1334 | 4143 | 4033 | 1.0274 | 1.0343 |
| SK-BR-3 | Seliciclib | 0.12 | uM | LJP5 | 72 | hr | 2543 | 5868 | 5752 | 1.0202 | 1.0343 |
| BT-20 | Fedratinib | 0.04 | uM | LJP5 | 72 | hr | 1334 | 4137 | 4033 | 1.0267 | 1.0338 |
| MCF7 | Enzastaurin | 0.37 | uM | LJP5 | 72 | hr | 1389 | 6125 | 5905 | 1.0364 | 1.0338 |
| Hs 578T | Vemurafenib | 0.12 | uM | LJP5 | 72 | hr | 765 | 3257 | 3148 | 1.0348 | 1.0338 |
| BT-20 | PLX-4720 | 0.04 | uM | LJP5 | 72 | hr | 1334 | 4142 | 4033 | 1.0270 | 1.0337 |
| SK-BR-3 | PD184352 | 0.37 | uM | LJP5 | 72 | hr | 2543 | 5866 | 5752 | 1.0198 | 1.0336 |
| BT-20 | LDN-193189 | 0.04 | uM | LJP5 | 72 | hr | 1334 | 4142 | 4033 | 1.0269 | 1.0334 |
| Hs 578T | JNK-9L | 0.04 | uM | LJP6 | 72 | hr | 765 | 3208 | 3101 | 1.0342 | 1.0334 |
| SK-BR-3 | Enzastaurin | 1.11 | uM | LJP5 | 72 | hr | 2543 | 5864 | 5752 | 1.0195 | 1.0331 |
| MCF7 | Lapatinib | 1.11 | uM | LJP6 | 72 | hr | 1389 | 5610 | 5445 | 1.0319 | 1.0331 |
| SK-BR-3 | Imatinib | 1.11 | uM | LJP6 | 72 | hr | 2543 | 5523 | 5418 | 1.0188 | 1.0331 |
| MCF 10A | CHIR-99021 | 0.37 | uM | LJP6 | 72 | hr | 1694 | 11724 | 11217 | 1.0453 | 1.0327 |
| BT-20 | Selumetinib | 10 | uM | LJP6 | 72 | hr | 1334 | 4027 | 3925 | 1.0259 | 1.0325 |
| SK-BR-3 | Linifanib | 1.11 | uM | LJP6 | 72 | hr | 2543 | 5508 | 5418 | 1.0171 | 1.0324 |
| BT-20 | PIK-93 | 0.12 | uM | LJP5 | 72 | hr | 1334 | 4135 | 4033 | 1.0257 | 1.0322 |
| BT-20 | Celastrol | 0.04 | uM | LJP6 | 72 | hr | 1334 | 4023 | 3925 | 1.0251 | 1.0321 |
| SK-BR-3 | Erlotinib | 0.37 | uM | LJP5 | 72 | hr | 2543 | 5861 | 5752 | 1.0189 | 1.0320 |