LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 12 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 2. - Dataset (ID:20249)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Normalized Growth Rate Inhibition Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | Withaferin A | 1.11 | uM | LJP6 | 72 | hr | 2543 | 1935 | 5418 | 0.3571 | -0.2224 |
| SK-BR-3 | Withaferin A | 3.33 | uM | LJP5 | 72 | hr | 2543 | 1817 | 5752 | 0.3160 | -0.2483 |
| SK-BR-3 | Withaferin A | 3.33 | uM | LJP6 | 72 | hr | 2543 | 1408 | 5418 | 0.2599 | -0.4189 |
| SK-BR-3 | Withaferin A | 10 | uM | LJP5 | 72 | hr | 2543 | 1381 | 5752 | 0.2402 | -0.4045 |
| SK-BR-3 | Withaferin A | 10 | uM | LJP6 | 72 | hr | 2543 | 1423 | 5418 | 0.2640 | -0.4123 |
| MDA-MB-231 | Seliciclib | 0.04 | uM | LJP5 | 72 | hr | 1311 | 5187 | 5079 | 1.0212 | 1.0216 |
| MDA-MB-231 | Seliciclib | 0.12 | uM | LJP5 | 72 | hr | 1311 | 5018 | 5079 | 0.9880 | 0.9877 |
| MDA-MB-231 | Seliciclib | 0.37 | uM | LJP5 | 72 | hr | 1311 | 4845 | 5079 | 0.9540 | 0.9520 |
| MDA-MB-231 | Seliciclib | 1.11 | uM | LJP5 | 72 | hr | 1311 | 4676 | 5079 | 0.9205 | 0.9167 |
| MDA-MB-231 | Seliciclib | 3.33 | uM | LJP5 | 72 | hr | 1311 | 4584 | 5079 | 0.9026 | 0.8978 |
| MDA-MB-231 | Seliciclib | 10 | uM | LJP5 | 72 | hr | 1311 | 2705 | 5079 | 0.5325 | 0.4483 |
| MDA-MB-231 | AT-7519 | 0.04 | uM | LJP6 | 72 | hr | 1311 | 3987 | 4935 | 0.8080 | 0.7889 |
| MDA-MB-231 | AT-7519 | 0.12 | uM | LJP6 | 72 | hr | 1311 | 2609 | 4935 | 0.5287 | 0.4328 |
| MDA-MB-231 | AT-7519 | 0.37 | uM | LJP6 | 72 | hr | 1311 | 913 | 4935 | 0.1852 | -0.1725 |
| MDA-MB-231 | AT-7519 | 1.11 | uM | LJP6 | 72 | hr | 1311 | 745 | 4935 | 0.1510 | -0.2564 |
| MDA-MB-231 | AT-7519 | 3.33 | uM | LJP6 | 72 | hr | 1311 | 613 | 4935 | 0.1243 | -0.3284 |
| MDA-MB-231 | AT-7519 | 10 | uM | LJP6 | 72 | hr | 1311 | 524 | 4935 | 0.1063 | -0.3811 |
| MDA-MB-231 | AZD7762 | 0.04 | uM | LJP6 | 72 | hr | 1311 | 4468 | 4935 | 0.9055 | 0.8988 |
| MDA-MB-231 | AZD7762 | 0.12 | uM | LJP6 | 72 | hr | 1311 | 2858 | 4935 | 0.5792 | 0.5030 |
| MDA-MB-231 | AZD7762 | 0.37 | uM | LJP6 | 72 | hr | 1311 | 2430 | 4935 | 0.4926 | 0.3808 |
| MDA-MB-231 | AZD7762 | 1.11 | uM | LJP6 | 72 | hr | 1311 | 1235 | 4935 | 0.2504 | -0.0309 |
| MDA-MB-231 | AZD7762 | 3.33 | uM | LJP6 | 72 | hr | 1311 | 785 | 4935 | 0.1593 | -0.2353 |
| MDA-MB-231 | AZD7762 | 10 | uM | LJP6 | 72 | hr | 1311 | 716 | 4935 | 0.1452 | -0.2722 |
| MDA-MB-231 | AZD8055 | 0.04 | uM | LJP6 | 72 | hr | 1311 | 2919 | 4935 | 0.5917 | 0.5182 |
| MDA-MB-231 | AZD8055 | 0.12 | uM | LJP6 | 72 | hr | 1311 | 2249 | 4935 | 0.4557 | 0.3244 |