LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 11 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 1. - Dataset (ID:20248)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Normalized Growth Rate Inhibition Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | Lapatinib | 0.04 | uM | LJP6 | 72 | hr | 1476 | 1530 | 3643 | 0.4194 | 0.0239 |
| SK-BR-3 | Lapatinib | 0.12 | uM | LJP6 | 72 | hr | 1476 | 1526 | 3643 | 0.4196 | 0.0254 |
| SK-BR-3 | Lapatinib | 0.37 | uM | LJP6 | 72 | hr | 1476 | 1511 | 3643 | 0.4154 | 0.0173 |
| SK-BR-3 | Lapatinib | 1.11 | uM | LJP6 | 72 | hr | 1476 | 1571 | 3643 | 0.4322 | 0.0490 |
| SK-BR-3 | Lapatinib | 3.33 | uM | LJP6 | 72 | hr | 1476 | 1542 | 3643 | 0.4228 | 0.0307 |
| SK-BR-3 | Lapatinib | 10 | uM | LJP6 | 72 | hr | 1476 | 1740 | 3643 | 0.4781 | 0.1330 |
| SK-BR-3 | Sirolimus | 0.04 | uM | LJP6 | 72 | hr | 1476 | 2466 | 3643 | 0.6749 | 0.4744 |
| SK-BR-3 | Sirolimus | 0.12 | uM | LJP6 | 72 | hr | 1476 | 2386 | 3643 | 0.6514 | 0.4309 |
| SK-BR-3 | Sirolimus | 0.37 | uM | LJP6 | 72 | hr | 1476 | 2196 | 3643 | 0.5986 | 0.3398 |
| SK-BR-3 | Sirolimus | 1.11 | uM | LJP6 | 72 | hr | 1476 | 2197 | 3643 | 0.5977 | 0.3343 |
| SK-BR-3 | Sirolimus | 3.33 | uM | LJP6 | 72 | hr | 1476 | 2134 | 3643 | 0.5816 | 0.3100 |
| SK-BR-3 | Sirolimus | 10 | uM | LJP6 | 72 | hr | 1476 | 2203 | 3643 | 0.6027 | 0.3510 |
| SK-BR-3 | ZSTK474 | 0.04 | uM | LJP6 | 72 | hr | 1476 | 3090 | 3643 | 0.8474 | 0.7592 |
| SK-BR-3 | ZSTK474 | 0.12 | uM | LJP6 | 72 | hr | 1476 | 2435 | 3643 | 0.6680 | 0.4654 |
| SK-BR-3 | ZSTK474 | 0.37 | uM | LJP6 | 72 | hr | 1476 | 1877 | 3643 | 0.5154 | 0.2001 |
| SK-BR-3 | ZSTK474 | 1.11 | uM | LJP6 | 72 | hr | 1476 | 1575 | 3643 | 0.4319 | 0.0475 |
| SK-BR-3 | ZSTK474 | 3.33 | uM | LJP6 | 72 | hr | 1476 | 1478 | 3643 | 0.4072 | 0.0017 |
| SK-BR-3 | ZSTK474 | 10 | uM | LJP6 | 72 | hr | 1476 | 1506 | 3643 | 0.4146 | 0.0160 |
| SK-BR-3 | BX-912 | 0.04 | uM | LJP5 | 72 | hr | 1476 | 2810 | 3772 | 0.7450 | 0.6082 |
| SK-BR-3 | BX-912 | 0.12 | uM | LJP5 | 72 | hr | 1476 | 2994 | 3772 | 0.7938 | 0.6859 |
| SK-BR-3 | BX-912 | 0.37 | uM | LJP5 | 72 | hr | 1476 | 1738 | 3772 | 0.4608 | 0.1280 |
| SK-BR-3 | BX-912 | 1.11 | uM | LJP5 | 72 | hr | 1476 | 1311 | 3772 | 0.3476 | -0.0843 |
| SK-BR-3 | BX-912 | 3.33 | uM | LJP5 | 72 | hr | 1476 | 1405 | 3772 | 0.3725 | -0.0363 |
| SK-BR-3 | BX-912 | 10 | uM | LJP5 | 72 | hr | 1476 | 1552 | 3772 | 0.4114 | 0.0372 |
| SK-BR-3 | Selumetinib | 0.04 | uM | LJP6 | 72 | hr | 1476 | 3967 | 3643 | 1.0903 | 1.1402 |