LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 11 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 1. - Dataset (ID:20248)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Normalized Growth Rate Inhibition Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF7 | Fedratinib | 1.11 | uM | LJP5 | 72 | hr | 1235 | 2443 | 4267 | 0.5726 | 0.4632 |
| MCF7 | Fedratinib | 3.33 | uM | LJP5 | 72 | hr | 1235 | 1226 | 4267 | 0.2874 | -0.0048 |
| MCF7 | Fedratinib | 10 | uM | LJP5 | 72 | hr | 1235 | 649 | 4267 | 0.1527 | -0.3035 |
| MCF7 | Trametinib | 0.04 | uM | LJP5 | 72 | hr | 1235 | 2062 | 4267 | 0.4833 | 0.3317 |
| MCF7 | Trametinib | 0.12 | uM | LJP5 | 72 | hr | 1235 | 2219 | 4267 | 0.5199 | 0.3868 |
| MCF7 | Trametinib | 0.37 | uM | LJP5 | 72 | hr | 1235 | 2126 | 4267 | 0.4977 | 0.3527 |
| MCF7 | Trametinib | 1.11 | uM | LJP5 | 72 | hr | 1235 | 2286 | 4267 | 0.5362 | 0.4110 |
| MCF7 | Trametinib | 3.33 | uM | LJP5 | 72 | hr | 1235 | 2307 | 4267 | 0.5413 | 0.4185 |
| MCF7 | Trametinib | 10 | uM | LJP5 | 72 | hr | 1235 | 2379 | 4267 | 0.5566 | 0.4392 |
| MCF7 | Omipalisib | 0.04 | uM | LJP6 | 72 | hr | 1235 | 1362 | 4056 | 0.3360 | 0.0585 |
| MCF7 | Omipalisib | 0.12 | uM | LJP6 | 72 | hr | 1235 | 1363 | 4056 | 0.3361 | 0.0591 |
| MCF7 | Omipalisib | 0.37 | uM | LJP6 | 72 | hr | 1235 | 1396 | 4056 | 0.3443 | 0.0739 |
| MCF7 | Omipalisib | 1.11 | uM | LJP6 | 72 | hr | 1235 | 1194 | 4056 | 0.2949 | -0.0197 |
| MCF7 | Omipalisib | 3.33 | uM | LJP6 | 72 | hr | 1235 | 1053 | 4056 | 0.2600 | -0.0886 |
| MCF7 | Omipalisib | 10 | uM | LJP6 | 72 | hr | 1235 | 822 | 4056 | 0.2029 | -0.2111 |
| MCF7 | Buparlisib | 0.04 | uM | LJP5 | 72 | hr | 1235 | 3877 | 4267 | 0.9078 | 0.8935 |
| MCF7 | Buparlisib | 0.12 | uM | LJP5 | 72 | hr | 1235 | 2627 | 4267 | 0.6161 | 0.5254 |
| MCF7 | Buparlisib | 0.37 | uM | LJP5 | 72 | hr | 1235 | 1528 | 4267 | 0.3580 | 0.1254 |
| MCF7 | Buparlisib | 1.11 | uM | LJP5 | 72 | hr | 1235 | 935 | 4267 | 0.2191 | -0.1448 |
| MCF7 | Buparlisib | 3.33 | uM | LJP5 | 72 | hr | 1235 | 854 | 4267 | 0.2002 | -0.1868 |
| MCF7 | Buparlisib | 10 | uM | LJP5 | 72 | hr | 1235 | 873 | 4267 | 0.2047 | -0.1765 |
| MCF7 | XL147 | 0.04 | uM | LJP5 | 72 | hr | 1235 | 4765 | 4267 | 1.1172 | 1.1282 |
| MCF7 | XL147 | 0.12 | uM | LJP5 | 72 | hr | 1235 | 4394 | 4267 | 1.0301 | 1.0337 |
| MCF7 | XL147 | 0.37 | uM | LJP5 | 72 | hr | 1235 | 4542 | 4267 | 1.0654 | 1.0727 |
| MCF7 | XL147 | 1.11 | uM | LJP5 | 72 | hr | 1235 | 4461 | 4267 | 1.0484 | 1.0518 |