LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 11 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 1. - Dataset (ID:20248)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Normalized Growth Rate Inhibition Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | A443654 | 10 | uM | LJP6 | 72 | hr | 929 | 684 | 3216 | 0.2125 | -0.1579 |
| MCF 10A | HG-6-64-01 | 10 | uM | LJP6 | 72 | hr | 513 | 246 | 10473 | 0.0235 | -0.1572 |
| BT-20 | Alvocidib | 0.37 | uM | LJP6 | 72 | hr | 1657 | 1244 | 5383 | 0.2310 | -0.1561 |
| SK-BR-3 | Fedratinib | 10 | uM | LJP5 | 72 | hr | 1476 | 1177 | 3772 | 0.3120 | -0.1559 |
| BT-20 | JNK-9L | 10 | uM | LJP6 | 72 | hr | 1657 | 1246 | 5383 | 0.2316 | -0.1549 |
| SK-BR-3 | HG-5-113-01 | 3.33 | uM | LJP5 | 72 | hr | 1476 | 1177 | 3772 | 0.3122 | -0.1541 |
| MCF7 | Dasatinib | 10 | uM | LJP5 | 72 | hr | 1235 | 918 | 4267 | 0.2150 | -0.1538 |
| SK-BR-3 | WZ3105 | 0.37 | uM | LJP5 | 72 | hr | 1476 | 1182 | 3772 | 0.3135 | -0.1536 |
| BT-20 | Torin2 | 10 | uM | LJP5 | 72 | hr | 1657 | 1242 | 5588 | 0.2225 | -0.1532 |
| MDA-MB-231 | CGP60474 | 1.11 | uM | LJP6 | 72 | hr | 868 | 621 | 3556 | 0.1750 | -0.1523 |
| SK-BR-3 | Alpelisib | 10 | uM | LJP5 | 72 | hr | 1476 | 1181 | 3772 | 0.3133 | -0.1523 |
| SK-BR-3 | BMS345541 | 10 | uM | LJP6 | 72 | hr | 1476 | 1195 | 3643 | 0.3279 | -0.1522 |
| SK-BR-3 | GW843682X | 3.33 | uM | LJP6 | 72 | hr | 1476 | 1194 | 3643 | 0.3284 | -0.1512 |
| MCF7 | BI-2536 | 10 | uM | LJP6 | 72 | hr | 1235 | 934 | 4056 | 0.2307 | -0.1511 |
| SK-BR-3 | Torin1 | 3.33 | uM | LJP6 | 72 | hr | 1476 | 1192 | 3643 | 0.3288 | -0.1507 |
| SK-BR-3 | Geldanamycin | 3.33 | uM | LJP6 | 72 | hr | 1476 | 1193 | 3643 | 0.3289 | -0.1503 |
| SK-BR-3 | A443654 | 1.11 | uM | LJP6 | 72 | hr | 1476 | 1195 | 3643 | 0.3289 | -0.1499 |
| MDA-MB-231 | CGP60474 | 3.33 | uM | LJP5 | 72 | hr | 868 | 631 | 3410 | 0.1851 | -0.1497 |
| MDA-MB-231 | Dasatinib | 10 | uM | LJP5 | 72 | hr | 868 | 633 | 3410 | 0.1857 | -0.1489 |
| Hs 578T | Foretinib | 10 | uM | LJP5 | 72 | hr | 929 | 697 | 3237 | 0.2153 | -0.1489 |
| SK-BR-3 | WH-4-025 | 10 | uM | LJP5 | 72 | hr | 1476 | 1188 | 3772 | 0.3150 | -0.1484 |
| SK-BR-3 | WZ3105 | 3.33 | uM | LJP5 | 72 | hr | 1476 | 1189 | 3772 | 0.3153 | -0.1480 |
| MDA-MB-231 | Foretinib | 10 | uM | LJP5 | 72 | hr | 868 | 635 | 3410 | 0.1864 | -0.1471 |
| SK-BR-3 | JNK-9L | 10 | uM | LJP6 | 72 | hr | 1476 | 1203 | 3643 | 0.3309 | -0.1460 |
| MCF7 | JNK-9L | 10 | uM | LJP6 | 72 | hr | 1235 | 944 | 4056 | 0.2327 | -0.1453 |