LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 4 of 15: Mean cell count and mean growth rate across biological replicate 1. - Dataset (ID:20240)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Relative Growth Rate After Treatment |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10A | WZ3105 | 3.33 | uM | LJP5 | 72 | hr | 513 | 615 | 10401 | 0.0592 | 0.0103 |
| MCF 10A | XMD11-50 | 3.33 | uM | LJP6 | 72 | hr | 513 | 1574 | 10401 | 0.1513 | 0.1073 |
| MCF 10A | Y39983 | 3.33 | uM | LJP6 | 72 | hr | 513 | 5400 | 10401 | 0.5192 | 0.4942 |
| MCF 10A | YM 201636 | 3.33 | uM | LJP5 | 72 | hr | 513 | 5196 | 10401 | 0.4996 | 0.4736 |
| MCF 10A | ZSTK474 | 3.33 | uM | LJP6 | 72 | hr | 513 | 1435 | 10401 | 0.1380 | 0.0933 |
| MCF 10A | Afatinib | 10.0 | uM | LJP6 | 72 | hr | 513 | 561 | 10401 | 0.0540 | 0.0049 |
| MCF 10A | Sigma A6730 | 10.0 | uM | LJP5 | 72 | hr | 513 | 2423 | 10401 | 0.2330 | 0.1932 |
| MCF 10A | Alvocidib | 10.0 | uM | LJP6 | 72 | hr | 513 | 467 | 10401 | 0.0450 | -0.0046 |
| MCF 10A | AT-7519 | 10.0 | uM | LJP6 | 72 | hr | 513 | 482 | 10401 | 0.0464 | -0.0031 |
| MCF 10A | AZD 5438 | 10.0 | uM | LJP6 | 72 | hr | 513 | 576 | 10401 | 0.0554 | 0.0064 |
| MCF 10A | AZD-6482 | 10.0 | uM | LJP5 | 72 | hr | 513 | 773 | 10401 | 0.0743 | 0.0263 |
| MCF 10A | AZD7762 | 10.0 | uM | LJP6 | 72 | hr | 513 | 353 | 10401 | 0.0340 | -0.0162 |
| MCF 10A | AZD8055 | 10.0 | uM | LJP6 | 72 | hr | 513 | 840 | 10401 | 0.0808 | 0.0330 |
| MCF 10A | AZD8330 | 10.0 | uM | LJP5 | 72 | hr | 513 | 577 | 10401 | 0.0555 | 0.0065 |
| MCF 10A | Barasertib | 10.0 | uM | LJP5 | 72 | hr | 513 | 1307 | 10401 | 0.1257 | 0.0803 |
| MCF 10A | BI-2536 | 10.0 | uM | LJP6 | 72 | hr | 513 | 760 | 10401 | 0.0731 | 0.0250 |
| MCF 10A | BMS345541 | 10.0 | uM | LJP6 | 72 | hr | 513 | 6788 | 10401 | 0.6527 | 0.6346 |
| MCF 10A | SNS-032 | 10.0 | uM | LJP6 | 72 | hr | 513 | 407 | 10401 | 0.0391 | -0.0108 |
| MCF 10A | GDC-0980 | 10.0 | uM | LJP5 | 72 | hr | 513 | 572 | 10401 | 0.0550 | 0.0059 |
| MCF 10A | NVP-AEW541 | 10.0 | uM | LJP5 | 72 | hr | 513 | 1146 | 10401 | 0.1102 | 0.0640 |
| MCF 10A | SB590885 | 10.0 | uM | LJP5 | 72 | hr | 513 | 4167 | 10401 | 0.4006 | 0.3695 |
| MCF 10A | PIK-93 | 10.0 | uM | LJP5 | 72 | hr | 513 | 2299 | 10401 | 0.2211 | 0.1807 |
| MCF 10A | KIN001-043 | 10.0 | uM | LJP6 | 72 | hr | 513 | 1892 | 10401 | 0.1819 | 0.1394 |
| MCF 10A | Alpelisib | 10.0 | uM | LJP5 | 72 | hr | 513 | 1516 | 10401 | 0.1458 | 0.1015 |
| MCF 10A | Luminespib | 10.0 | uM | LJP5 | 72 | hr | 513 | 535 | 10401 | 0.0514 | 0.0022 |