LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 4 of 15: Mean cell count and mean growth rate across biological replicate 1. - Dataset (ID:20240)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Relative Growth Rate After Treatment |
|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | A443654 | 1.11 | uM | LJP6 | 72 | hr | 1657 | 1225 | 5505 | 0.2225 | -0.1125 |
| MCF7 | Dasatinib | 0.37 | uM | LJP5 | 72 | hr | 1235 | 906 | 4156 | 0.2182 | -0.1125 |
| SK-BR-3 | Afatinib | 10.0 | uM | LJP6 | 72 | hr | 1476 | 1228 | 3694 | 0.3326 | -0.1119 |
| BT-20 | QL-X-138 | 10.0 | uM | LJP6 | 72 | hr | 1657 | 1231 | 5505 | 0.2237 | -0.1108 |
| SK-BR-3 | Withaferin A | 1.11 | uM | LJP6 | 72 | hr | 1476 | 1234 | 3694 | 0.3341 | -0.1095 |
| MDA-MB-231 | Dasatinib | 0.12 | uM | LJP6 | 72 | hr | 868 | 581 | 3486 | 0.1668 | -0.1094 |
| MCF7 | Dasatinib | 3.33 | uM | LJP6 | 72 | hr | 1235 | 916 | 4156 | 0.2204 | -0.1094 |
| SK-BR-3 | WZ3105 | 0.12 | uM | LJP5 | 72 | hr | 1476 | 1234 | 3694 | 0.3342 | -0.1092 |
| SK-BR-3 | WZ3105 | 1.11 | uM | LJP5 | 72 | hr | 1476 | 1235 | 3694 | 0.3343 | -0.1090 |
| SK-BR-3 | A443654 | 0.12 | uM | LJP6 | 72 | hr | 1476 | 1235 | 3694 | 0.3345 | -0.1087 |
| MCF7 | Dasatinib | 10.0 | uM | LJP5 | 72 | hr | 1235 | 918 | 4156 | 0.2210 | -0.1086 |
| BT-20 | Torin1 | 3.33 | uM | LJP6 | 72 | hr | 1657 | 1240 | 5505 | 0.2252 | -0.1086 |
| SK-BR-3 | Tozasertib | 0.37 | uM | LJP5 | 72 | hr | 1476 | 1236 | 3694 | 0.3348 | -0.1083 |
| BT-20 | GW843682X | 3.33 | uM | LJP6 | 72 | hr | 1657 | 1241 | 5505 | 0.2255 | -0.1082 |
| BT-20 | Torin2 | 10.0 | uM | LJP5 | 72 | hr | 1657 | 1242 | 5505 | 0.2257 | -0.1080 |
| MDA-MB-231 | GSK1059615 | 10.0 | uM | LJP5 | 72 | hr | 868 | 586 | 3486 | 0.1682 | -0.1076 |
| MDA-MB-231 | CGP60474 | 10.0 | uM | LJP5 | 72 | hr | 868 | 586 | 3486 | 0.1683 | -0.1075 |
| BT-20 | Alvocidib | 0.37 | uM | LJP6 | 72 | hr | 1657 | 1244 | 5505 | 0.2261 | -0.1074 |
| Hs 578T | HG-6-64-01 | 10.0 | uM | LJP6 | 72 | hr | 929 | 682 | 3228 | 0.2114 | -0.1074 |
| BT-20 | JNK-9L | 10.0 | uM | LJP6 | 72 | hr | 1657 | 1246 | 5505 | 0.2264 | -0.1068 |
| Hs 578T | A443654 | 10.0 | uM | LJP6 | 72 | hr | 929 | 684 | 3228 | 0.2119 | -0.1067 |
| MDA-MB-231 | AT-7519 | 3.33 | uM | LJP6 | 72 | hr | 868 | 588 | 3486 | 0.1689 | -0.1067 |
| SK-BR-3 | Y39983 | 10.0 | uM | LJP6 | 72 | hr | 1476 | 1243 | 3694 | 0.3366 | -0.1053 |
| SK-BR-3 | Celastrol | 1.11 | uM | LJP6 | 72 | hr | 1476 | 1243 | 3694 | 0.3367 | -0.1051 |
| SK-BR-3 | PF562271 | 10.0 | uM | LJP6 | 72 | hr | 1476 | 1246 | 3694 | 0.3375 | -0.1038 |