LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 4 of 15: Mean cell count and mean growth rate across biological replicate 1. - Dataset (ID:20240)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Relative Growth Rate After Treatment |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-231 | AT-7519 | 1.11 | uM | LJP6 | 72 | hr | 868 | 722 | 3486 | 0.2073 | -0.0556 |
| MCF7 | CGP60474 | 1.11 | uM | LJP5 | 72 | hr | 1235 | 861 | 4156 | 0.2073 | -0.1280 |
| SK-BR-3 | Omipalisib | 10.0 | uM | LJP6 | 72 | hr | 1476 | 765 | 3694 | 0.2073 | -0.3207 |
| Hs 578T | CGP60474 | 10.0 | uM | LJP6 | 72 | hr | 929 | 669 | 3228 | 0.2074 | -0.1131 |
| BT-20 | A443654 | 3.33 | uM | LJP6 | 72 | hr | 1657 | 1142 | 5505 | 0.2075 | -0.1339 |
| BT-20 | WH-4-025 | 10.0 | uM | LJP5 | 72 | hr | 1657 | 1145 | 5505 | 0.2080 | -0.1332 |
| MCF7 | BMS345541 | 10.0 | uM | LJP6 | 72 | hr | 1235 | 866 | 4156 | 0.2084 | -0.1265 |
| MCF 10A | Pictilisib | 0.37 | uM | LJP6 | 72 | hr | 513 | 2168 | 10401 | 0.2085 | 0.1674 |
| BT-20 | SNS-032 | 10.0 | uM | LJP6 | 72 | hr | 1657 | 1155 | 5505 | 0.2098 | -0.1307 |
| MDA-MB-231 | Afatinib | 10.0 | uM | LJP6 | 72 | hr | 868 | 732 | 3486 | 0.2101 | -0.0519 |
| MCF7 | Buparlisib | 10.0 | uM | LJP5 | 72 | hr | 1235 | 873 | 4156 | 0.2102 | -0.1238 |
| BT-20 | Dasatinib | 3.33 | uM | LJP6 | 72 | hr | 1657 | 1159 | 5505 | 0.2106 | -0.1294 |
| MDA-MB-231 | WZ3105 | 0.37 | uM | LJP5 | 72 | hr | 868 | 735 | 3486 | 0.2108 | -0.0508 |
| MDA-MB-231 | Dasatinib | 0.12 | uM | LJP5 | 72 | hr | 868 | 736 | 3486 | 0.2113 | -0.0502 |
| Hs 578T | HG-6-64-01 | 10.0 | uM | LJP6 | 72 | hr | 929 | 682 | 3228 | 0.2114 | -0.1074 |
| MCF 10A | Selumetinib | 0.12 | uM | LJP6 | 72 | hr | 513 | 2200 | 10401 | 0.2116 | 0.1706 |
| Hs 578T | A443654 | 10.0 | uM | LJP6 | 72 | hr | 929 | 684 | 3228 | 0.2119 | -0.1067 |
| BT-20 | Alvocidib | 10.0 | uM | LJP6 | 72 | hr | 1657 | 1169 | 5505 | 0.2124 | -0.1269 |
| MCF 10A | GSK1904529A | 3.33 | uM | LJP6 | 72 | hr | 513 | 2209 | 10401 | 0.2124 | 0.1715 |
| MCF7 | HG-5-113-01 | 10.0 | uM | LJP5 | 72 | hr | 1235 | 883 | 4156 | 0.2125 | -0.1207 |
| MCF7 | WZ3105 | 0.37 | uM | LJP5 | 72 | hr | 1235 | 883 | 4156 | 0.2126 | -0.1204 |
| MCF 10A | Dovitinib | 1.11 | uM | LJP5 | 72 | hr | 513 | 2212 | 10401 | 0.2127 | 0.1718 |
| SK-BR-3 | AT-7519 | 10.0 | uM | LJP6 | 72 | hr | 1476 | 788 | 3694 | 0.2133 | -0.3106 |
| BT-20 | CGP60474 | 10.0 | uM | LJP5 | 72 | hr | 1657 | 1176 | 5505 | 0.2136 | -0.1252 |
| MDA-MB-231 | SNS-032 | 1.11 | uM | LJP6 | 72 | hr | 868 | 748 | 3486 | 0.2146 | -0.0458 |