LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 4 of 15: Mean cell count and mean growth rate across biological replicate 1. - Dataset (ID:20240)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Relative Growth Rate After Treatment |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | JNK-9L | 0.12 | uM | LJP6 | 72 | hr | 929 | 3394 | 3228 | 1.0514 | 1.0722 |
| MCF 10A | Linifanib | 0.12 | uM | LJP6 | 72 | hr | 513 | 11112 | 10401 | 1.0684 | 1.0720 |
| MCF 10A | HG-6-64-01 | 0.04 | uM | LJP6 | 72 | hr | 513 | 11110 | 10401 | 1.0682 | 1.0717 |
| Hs 578T | Celastrol | 0.04 | uM | LJP6 | 72 | hr | 929 | 3393 | 3228 | 1.0511 | 1.0717 |
| MDA-MB-231 | XL147 | 0.12 | uM | LJP5 | 72 | hr | 868 | 3671 | 3486 | 1.0531 | 1.0708 |
| MDA-MB-231 | Gefitinib | 0.37 | uM | LJP6 | 72 | hr | 868 | 3668 | 3486 | 1.0522 | 1.0695 |
| Hs 578T | YM 201636 | 0.04 | uM | LJP5 | 72 | hr | 929 | 3387 | 3228 | 1.0492 | 1.0691 |
| MDA-MB-231 | BMS345541 | 0.12 | uM | LJP6 | 72 | hr | 868 | 3667 | 3486 | 1.0518 | 1.0690 |
| BT-20 | PD184352 | 0.04 | uM | LJP5 | 72 | hr | 1657 | 5766 | 5505 | 1.0473 | 1.0677 |
| BT-20 | NVP-AEW541 | 0.37 | uM | LJP5 | 72 | hr | 1657 | 5765 | 5505 | 1.0471 | 1.0674 |
| MDA-MB-231 | Pelitinib | 0.12 | uM | LJP5 | 72 | hr | 868 | 3662 | 3486 | 1.0505 | 1.0672 |
| MCF7 | Enzastaurin | 0.37 | uM | LJP5 | 72 | hr | 1235 | 4352 | 4156 | 1.0472 | 1.0672 |
| SK-BR-3 | WH-4-025 | 0.04 | uM | LJP5 | 72 | hr | 1476 | 3842 | 3694 | 1.0402 | 1.0670 |
| BT-20 | Linifanib | 0.12 | uM | LJP6 | 72 | hr | 1657 | 5763 | 5505 | 1.0469 | 1.0670 |
| BT-20 | Gefitinib | 0.04 | uM | LJP6 | 72 | hr | 1657 | 5762 | 5505 | 1.0466 | 1.0667 |
| SK-BR-3 | Imatinib | 0.12 | uM | LJP6 | 72 | hr | 1476 | 3841 | 3694 | 1.0400 | 1.0666 |
| BT-20 | XL147 | 0.12 | uM | LJP5 | 72 | hr | 1657 | 5761 | 5505 | 1.0465 | 1.0665 |
| MCF7 | Nilotinib | 3.33 | uM | LJP5 | 72 | hr | 1235 | 4349 | 4156 | 1.0466 | 1.0662 |
| MDA-MB-231 | XL147 | 0.37 | uM | LJP5 | 72 | hr | 868 | 3659 | 3486 | 1.0497 | 1.0662 |
| BT-20 | Alpelisib | 0.04 | uM | LJP5 | 72 | hr | 1657 | 5760 | 5505 | 1.0462 | 1.0661 |
| Hs 578T | KIN001-043 | 0.37 | uM | LJP6 | 72 | hr | 929 | 3379 | 3228 | 1.0469 | 1.0658 |
| BT-20 | Imatinib | 0.12 | uM | LJP6 | 72 | hr | 1657 | 5758 | 5505 | 1.0460 | 1.0657 |
| SK-BR-3 | R406 | 0.04 | uM | LJP6 | 72 | hr | 1476 | 3838 | 3694 | 1.0390 | 1.0649 |
| BT-20 | CP466722 | 1.11 | uM | LJP5 | 72 | hr | 1657 | 5755 | 5505 | 1.0453 | 1.0649 |
| MCF7 | Erlotinib | 0.37 | uM | LJP5 | 72 | hr | 1235 | 4342 | 4156 | 1.0447 | 1.0636 |