PLSR model loadings (pMEK and pERK included) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20229)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| MZ7-mel | 1 | hr | pMEK(S217/221) | 3.65630 | -1.83970 |
| MZ7-mel | 1 | hr | pERK(T202/Y204) | 9.50630 | 1.06100 |
| MZ7-mel | 1 | hr | p-p90RSK(S380) | 0.55226 | -0.27172 |
| MZ7-mel | 1 | hr | p-p90RSK(T573) | -0.02634 | -0.37894 |
| MZ7-mel | 1 | hr | p-AKT(T308) | 0.48766 | -0.10199 |
| MZ7-mel | 1 | hr | p-AKT(S473) | 0.95400 | -0.21893 |
| MZ7-mel | 1 | hr | p-mTOR(S2448) | 0.16146 | -0.06509 |
| MZ7-mel | 1 | hr | p-p70S6K(T421/S424) | 0.55515 | -0.00165 |
| MZ7-mel | 1 | hr | p-p70S6K(T389) | 0.85067 | -0.08149 |
| MZ7-mel | 1 | hr | p-S6(S235/236) | 1.50360 | -0.08786 |
| MZ7-mel | 1 | hr | p-AMPK(T172) | -0.17616 | -0.24275 |
| MZ7-mel | 1 | hr | p-JNK(T183/Y185) | 0.31439 | -0.11376 |
| MZ7-mel | 1 | hr | Total c-Jun | 0.70471 | -0.03593 |
| MZ7-mel | 1 | hr | p-cJun(S63) | 0.23829 | -0.09706 |
| MZ7-mel | 1 | hr | p-P38(T180/Y182) | 1.00370 | -0.24282 |
| MZ7-mel | 1 | hr | p-HSP27(S82) | 0.19112 | -0.19172 |
| MZ7-mel | 1 | hr | p-NFKB(S536) | 0.17757 | -0.14723 |
| MZ7-mel | 1 | hr | Bim | -0.13511 | -0.21885 |
| MZ7-mel | 1 | hr | cPARP | 0.12279 | -0.34958 |
| MZ7-mel | 1 | hr | p-Histone H3(S10) | -0.35119 | -0.43789 |
| MZ7-mel | 1 | hr | p27 Kip1 | 0.26359 | -0.17733 |
| MZ7-mel | 5 | hr | pMEK(S217/221) | 2.78840 | -2.26900 |
| MZ7-mel | 5 | hr | pERK(T202/Y204) | 8.81340 | -0.32746 |
| MZ7-mel | 5 | hr | p-p90RSK(S380) | -0.35252 | -1.08360 |
| MZ7-mel | 5 | hr | p-p90RSK(T573) | -0.90312 | -0.78207 |