PLSR model loadings (pMEK and pERK included) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20229)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| K2 | 24 | hr | p-p90RSK(S380) | -1.97520 | 0.14351 |
| K2 | 24 | hr | p-p90RSK(T573) | -1.15610 | -0.09859 |
| K2 | 24 | hr | p-AKT(T308) | NaN | NaN |
| K2 | 24 | hr | p-AKT(S473) | -3.44610 | 0.32810 |
| K2 | 24 | hr | p-mTOR(S2448) | -0.74897 | 0.25577 |
| K2 | 24 | hr | p-p70S6K(T421/S424) | -0.85518 | 0.12891 |
| K2 | 24 | hr | p-p70S6K(T389) | 1.59960 | 0.35027 |
| K2 | 24 | hr | p-S6(S235/236) | 4.89650 | 0.39146 |
| K2 | 24 | hr | p-AMPK(T172) | 0.25555 | 0.40506 |
| K2 | 24 | hr | p-JNK(T183/Y185) | -2.48560 | 0.05495 |
| K2 | 24 | hr | Total c-Jun | -1.18900 | 0.30422 |
| K2 | 24 | hr | p-cJun(S63) | -1.35890 | 0.33625 |
| K2 | 24 | hr | p-P38(T180/Y182) | -2.17070 | -0.40029 |
| K2 | 24 | hr | p-HSP27(S82) | -2.77680 | 0.17225 |
| K2 | 24 | hr | p-NFKB(S536) | -2.04010 | 0.01118 |
| K2 | 24 | hr | Bim | -5.14450 | -0.22263 |
| K2 | 24 | hr | cPARP | -2.92570 | -0.26219 |
| K2 | 24 | hr | p-Histone H3(S10) | 3.88010 | 0.58744 |
| K2 | 24 | hr | p27 Kip1 | -4.95450 | -0.40833 |
| K2 | 48 | hr | pMEK(S217/221) | 2.71360 | -5.74430 |
| K2 | 48 | hr | pERK(T202/Y204) | 4.34190 | -0.03649 |
| K2 | 48 | hr | p-p90RSK(S380) | -2.41140 | -0.16412 |
| K2 | 48 | hr | p-p90RSK(T573) | -1.66450 | -0.40273 |
| K2 | 48 | hr | p-AKT(T308) | NaN | NaN |
| K2 | 48 | hr | p-AKT(S473) | -4.07470 | -0.50698 |