PLSR model loadings (pMEK and pERK included) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20229)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| C32 | 5 | hr | p-AKT(T308) | -0.34603 | -0.05805 |
| C32 | 5 | hr | p-AKT(S473) | -0.89262 | 0.16765 |
| C32 | 5 | hr | p-mTOR(S2448) | NaN | NaN |
| C32 | 5 | hr | p-p70S6K(T421/S424) | 0.48333 | -0.35367 |
| C32 | 5 | hr | p-p70S6K(T389) | NaN | NaN |
| C32 | 5 | hr | p-S6(S235/236) | 2.70650 | -0.68903 |
| C32 | 5 | hr | p-AMPK(T172) | -0.53619 | -0.09893 |
| C32 | 5 | hr | p-JNK(T183/Y185) | 0.00978 | -0.94781 |
| C32 | 5 | hr | Total c-Jun | 2.01540 | -0.30253 |
| C32 | 5 | hr | p-cJun(S63) | NaN | NaN |
| C32 | 5 | hr | p-P38(T180/Y182) | -0.04272 | -0.22597 |
| C32 | 5 | hr | p-HSP27(S82) | NaN | NaN |
| C32 | 5 | hr | p-NFKB(S536) | 0.81013 | -0.20262 |
| C32 | 5 | hr | Bim | -0.88685 | -0.00581 |
| C32 | 5 | hr | cPARP | 0.19076 | -0.14485 |
| C32 | 5 | hr | p-Histone H3(S10) | -1.16240 | 0.38982 |
| C32 | 5 | hr | p27 Kip1 | -0.32568 | -0.29943 |
| C32 | 10 | hr | pMEK(S217/221) | 2.58930 | -1.40120 |
| C32 | 10 | hr | pERK(T202/Y204) | 6.52490 | 0.32054 |
| C32 | 10 | hr | p-p90RSK(S380) | NaN | NaN |
| C32 | 10 | hr | p-p90RSK(T573) | -0.27374 | -0.92710 |
| C32 | 10 | hr | p-AKT(T308) | -0.51487 | -0.10240 |
| C32 | 10 | hr | p-AKT(S473) | -1.06350 | 0.45684 |
| C32 | 10 | hr | p-mTOR(S2448) | NaN | NaN |
| C32 | 10 | hr | p-p70S6K(T421/S424) | 0.69100 | -0.52955 |