PLSR model loadings (pMEK and pERK included) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20229)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| C32 | 10 | hr | p-p70S6K(T389) | NaN | NaN |
| C32 | 10 | hr | p-S6(S235/236) | 3.45750 | -1.16530 |
| C32 | 10 | hr | p-AMPK(T172) | -0.37935 | 0.00337 |
| C32 | 10 | hr | p-JNK(T183/Y185) | 0.18395 | -0.90060 |
| C32 | 10 | hr | Total c-Jun | 3.09320 | -0.06927 |
| C32 | 10 | hr | p-cJun(S63) | NaN | NaN |
| C32 | 10 | hr | p-P38(T180/Y182) | -0.15625 | -0.38272 |
| C32 | 10 | hr | p-HSP27(S82) | NaN | NaN |
| C32 | 10 | hr | p-NFKB(S536) | 0.93640 | -0.19404 |
| C32 | 10 | hr | Bim | -0.77867 | -0.16369 |
| C32 | 10 | hr | cPARP | -0.09249 | -0.18915 |
| C32 | 10 | hr | p-Histone H3(S10) | -0.96184 | -0.01447 |
| C32 | 10 | hr | p27 Kip1 | -0.73413 | -0.48606 |
| C32 | 24 | hr | pMEK(S217/221) | 2.31300 | -1.25720 |
| C32 | 24 | hr | pERK(T202/Y204) | 5.72980 | 0.40993 |
| C32 | 24 | hr | p-p90RSK(S380) | NaN | NaN |
| C32 | 24 | hr | p-p90RSK(T573) | 0.58308 | -0.57929 |
| C32 | 24 | hr | p-AKT(T308) | -0.97853 | 0.04129 |
| C32 | 24 | hr | p-AKT(S473) | -1.04740 | 0.70251 |
| C32 | 24 | hr | p-mTOR(S2448) | NaN | NaN |
| C32 | 24 | hr | p-p70S6K(T421/S424) | 1.51010 | -0.32289 |
| C32 | 24 | hr | p-p70S6K(T389) | NaN | NaN |
| C32 | 24 | hr | p-S6(S235/236) | 4.29770 | -1.34810 |
| C32 | 24 | hr | p-AMPK(T172) | -1.17880 | 0.10569 |
| C32 | 24 | hr | p-JNK(T183/Y185) | -0.21356 | -0.75132 |