PLSR model loadings (pMEK and pERK included) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20229)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| K2 | 5 | hr | p-Histone H3(S10) | -2.01300 | 0.00316 |
| K2 | 5 | hr | p27 Kip1 | -0.90704 | 0.01024 |
| K2 | 10 | hr | pMEK(S217/221) | 6.04980 | -5.58850 |
| K2 | 10 | hr | pERK(T202/Y204) | 9.61160 | 1.06950 |
| K2 | 10 | hr | p-p90RSK(S380) | 1.14340 | 0.02050 |
| K2 | 10 | hr | p-p90RSK(T573) | 0.86412 | -0.10965 |
| K2 | 10 | hr | p-AKT(T308) | NaN | NaN |
| K2 | 10 | hr | p-AKT(S473) | 0.01553 | 0.13520 |
| K2 | 10 | hr | p-mTOR(S2448) | 0.91460 | -0.04945 |
| K2 | 10 | hr | p-p70S6K(T421/S424) | 1.43120 | -0.01179 |
| K2 | 10 | hr | p-p70S6K(T389) | 3.23740 | 0.02634 |
| K2 | 10 | hr | p-S6(S235/236) | 6.28610 | 0.42465 |
| K2 | 10 | hr | p-AMPK(T172) | 1.09610 | -0.16772 |
| K2 | 10 | hr | p-JNK(T183/Y185) | 1.27580 | -0.05887 |
| K2 | 10 | hr | Total c-Jun | 2.45730 | 0.05269 |
| K2 | 10 | hr | p-cJun(S63) | 1.90960 | 0.12645 |
| K2 | 10 | hr | p-P38(T180/Y182) | 1.04910 | -0.37919 |
| K2 | 10 | hr | p-HSP27(S82) | 0.85516 | -0.05513 |
| K2 | 10 | hr | p-NFKB(S536) | 0.68233 | -0.00334 |
| K2 | 10 | hr | Bim | -0.41460 | -0.32815 |
| K2 | 10 | hr | cPARP | 0.41433 | -0.11464 |
| K2 | 10 | hr | p-Histone H3(S10) | -0.77953 | -0.13356 |
| K2 | 10 | hr | p27 Kip1 | -1.34810 | -0.19965 |
| K2 | 24 | hr | pMEK(S217/221) | 3.57990 | -5.36320 |
| K2 | 24 | hr | pERK(T202/Y204) | 5.51070 | 0.87128 |