PLSR model loadings (pMEK and pERK included) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20229)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| K2 | 1 | hr | p-HSP27(S82) | 0.63952 | -0.28587 |
| K2 | 1 | hr | p-NFKB(S536) | 0.29398 | -0.13852 |
| K2 | 1 | hr | Bim | 0.49984 | -0.39665 |
| K2 | 1 | hr | cPARP | 0.31440 | -0.14535 |
| K2 | 1 | hr | p-Histone H3(S10) | 0.08862 | -0.15508 |
| K2 | 1 | hr | p27 Kip1 | 0.33128 | -0.00180 |
| K2 | 5 | hr | pMEK(S217/221) | 4.26630 | -5.01600 |
| K2 | 5 | hr | pERK(T202/Y204) | 8.46880 | 1.30340 |
| K2 | 5 | hr | p-p90RSK(S380) | -0.31708 | 0.18157 |
| K2 | 5 | hr | p-p90RSK(T573) | -0.33709 | -0.18118 |
| K2 | 5 | hr | p-AKT(T308) | NaN | NaN |
| K2 | 5 | hr | p-AKT(S473) | -1.23070 | 0.08861 |
| K2 | 5 | hr | p-mTOR(S2448) | -0.78859 | -0.03840 |
| K2 | 5 | hr | p-p70S6K(T421/S424) | -0.49141 | 0.09269 |
| K2 | 5 | hr | p-p70S6K(T389) | 0.93690 | 0.26060 |
| K2 | 5 | hr | p-S6(S235/236) | 1.78970 | -0.03500 |
| K2 | 5 | hr | p-AMPK(T172) | -1.04710 | -0.25673 |
| K2 | 5 | hr | p-JNK(T183/Y185) | -0.91350 | 0.11905 |
| K2 | 5 | hr | Total c-Jun | 0.85293 | 0.18310 |
| K2 | 5 | hr | p-cJun(S63) | 0.24696 | 0.09114 |
| K2 | 5 | hr | p-P38(T180/Y182) | -0.48809 | -0.15335 |
| K2 | 5 | hr | p-HSP27(S82) | -0.77078 | 0.20206 |
| K2 | 5 | hr | p-NFKB(S536) | -1.07650 | 0.23701 |
| K2 | 5 | hr | Bim | -2.07340 | -0.07290 |
| K2 | 5 | hr | cPARP | -1.02560 | 0.17606 |