PLSR model loadings (pMEK and pERK included) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20229)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| MZ7-mel | 5 | hr | p-AKT(T308) | -0.59428 | -0.77035 |
| MZ7-mel | 5 | hr | p-AKT(S473) | -0.73272 | -1.11080 |
| MZ7-mel | 5 | hr | p-mTOR(S2448) | -0.44300 | -0.61417 |
| MZ7-mel | 5 | hr | p-p70S6K(T421/S424) | -0.25690 | -0.77446 |
| MZ7-mel | 5 | hr | p-p70S6K(T389) | -0.31605 | -0.97484 |
| MZ7-mel | 5 | hr | p-S6(S235/236) | 1.60980 | -0.72053 |
| MZ7-mel | 5 | hr | p-AMPK(T172) | -1.03540 | -0.76726 |
| MZ7-mel | 5 | hr | p-JNK(T183/Y185) | -0.85686 | -1.12640 |
| MZ7-mel | 5 | hr | Total c-Jun | 0.36162 | -0.35812 |
| MZ7-mel | 5 | hr | p-cJun(S63) | -0.80333 | -0.96463 |
| MZ7-mel | 5 | hr | p-P38(T180/Y182) | -0.06873 | -1.24310 |
| MZ7-mel | 5 | hr | p-HSP27(S82) | -0.70747 | -0.71981 |
| MZ7-mel | 5 | hr | p-NFKB(S536) | -0.36757 | -0.64203 |
| MZ7-mel | 5 | hr | Bim | -1.54470 | -1.36110 |
| MZ7-mel | 5 | hr | cPARP | -0.69979 | -0.72304 |
| MZ7-mel | 5 | hr | p-Histone H3(S10) | -1.16230 | -0.64056 |
| MZ7-mel | 5 | hr | p27 Kip1 | -0.65100 | -0.65674 |
| MZ7-mel | 10 | hr | pMEK(S217/221) | 4.47360 | -1.33890 |
| MZ7-mel | 10 | hr | pERK(T202/Y204) | 10.72900 | 0.27725 |
| MZ7-mel | 10 | hr | p-p90RSK(S380) | 0.92807 | -0.10742 |
| MZ7-mel | 10 | hr | p-p90RSK(T573) | 0.05237 | -0.14992 |
| MZ7-mel | 10 | hr | p-AKT(T308) | -0.02746 | -0.19614 |
| MZ7-mel | 10 | hr | p-AKT(S473) | 0.74008 | -0.43971 |
| MZ7-mel | 10 | hr | p-mTOR(S2448) | 0.26138 | -0.00725 |
| MZ7-mel | 10 | hr | p-p70S6K(T421/S424) | 0.72185 | -0.04982 |