PLSR model loadings (pMEK and pERK included) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20229)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| MZ7-mel | 10 | hr | p-p70S6K(T389) | 0.70486 | -0.04819 |
| MZ7-mel | 10 | hr | p-S6(S235/236) | 4.73880 | 0.44933 |
| MZ7-mel | 10 | hr | p-AMPK(T172) | -0.35369 | -0.45966 |
| MZ7-mel | 10 | hr | p-JNK(T183/Y185) | 0.84035 | -0.07176 |
| MZ7-mel | 10 | hr | Total c-Jun | 1.09420 | 0.30007 |
| MZ7-mel | 10 | hr | p-cJun(S63) | 0.36867 | -0.06204 |
| MZ7-mel | 10 | hr | p-P38(T180/Y182) | 0.68211 | -0.17834 |
| MZ7-mel | 10 | hr | p-HSP27(S82) | 0.25789 | -0.12412 |
| MZ7-mel | 10 | hr | p-NFKB(S536) | 0.81368 | -0.09150 |
| MZ7-mel | 10 | hr | Bim | -0.35817 | -0.42368 |
| MZ7-mel | 10 | hr | cPARP | -0.15492 | -0.18445 |
| MZ7-mel | 10 | hr | p-Histone H3(S10) | -0.69427 | -0.24236 |
| MZ7-mel | 10 | hr | p27 Kip1 | -0.61789 | -0.16830 |
| MZ7-mel | 24 | hr | pMEK(S217/221) | 3.62400 | -1.44320 |
| MZ7-mel | 24 | hr | pERK(T202/Y204) | 8.57930 | 0.08201 |
| MZ7-mel | 24 | hr | p-p90RSK(S380) | -0.22683 | -0.65404 |
| MZ7-mel | 24 | hr | p-p90RSK(T573) | 0.87153 | -0.01927 |
| MZ7-mel | 24 | hr | p-AKT(T308) | -0.76247 | -0.49435 |
| MZ7-mel | 24 | hr | p-AKT(S473) | -0.46861 | -0.51382 |
| MZ7-mel | 24 | hr | p-mTOR(S2448) | -0.46399 | -0.35294 |
| MZ7-mel | 24 | hr | p-p70S6K(T421/S424) | 0.46604 | -0.28404 |
| MZ7-mel | 24 | hr | p-p70S6K(T389) | 0.03572 | -0.93932 |
| MZ7-mel | 24 | hr | p-S6(S235/236) | 7.48310 | 0.34108 |
| MZ7-mel | 24 | hr | p-AMPK(T172) | -0.84265 | -0.38660 |
| MZ7-mel | 24 | hr | p-JNK(T183/Y185) | -0.73746 | -0.72310 |