PLSR model loadings (pMEK and pERK included) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20229)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| LOXIMVI | 1 | hr | p-AMPK(T172) | 1.33460 | -0.37751 |
| LOXIMVI | 1 | hr | p-JNK(T183/Y185) | 1.29370 | -0.49629 |
| LOXIMVI | 1 | hr | Total c-Jun | 1.22670 | -0.57348 |
| LOXIMVI | 1 | hr | p-cJun(S63) | 1.12700 | -0.45721 |
| LOXIMVI | 1 | hr | p-P38(T180/Y182) | 3.06110 | -2.68300 |
| LOXIMVI | 1 | hr | p-HSP27(S82) | 1.08410 | -0.50000 |
| LOXIMVI | 1 | hr | p-NFKB(S536) | 0.99121 | -0.35991 |
| LOXIMVI | 1 | hr | Bim | 1.89310 | -0.30201 |
| LOXIMVI | 1 | hr | cPARP | 1.09540 | -0.28306 |
| LOXIMVI | 1 | hr | p-Histone H3(S10) | 0.37486 | 0.64204 |
| LOXIMVI | 1 | hr | p27 Kip1 | 1.44280 | -0.79372 |
| LOXIMVI | 5 | hr | pMEK(S217/221) | 0.53975 | -4.08460 |
| LOXIMVI | 5 | hr | pERK(T202/Y204) | 3.01990 | -0.43901 |
| LOXIMVI | 5 | hr | p-p90RSK(S380) | 0.32683 | 0.72858 |
| LOXIMVI | 5 | hr | p-p90RSK(T573) | 0.51262 | 0.27323 |
| LOXIMVI | 5 | hr | p-AKT(T308) | NaN | NaN |
| LOXIMVI | 5 | hr | p-AKT(S473) | -0.28148 | 1.35810 |
| LOXIMVI | 5 | hr | p-mTOR(S2448) | 0.13649 | 1.03060 |
| LOXIMVI | 5 | hr | p-p70S6K(T421/S424) | 0.09393 | 1.53030 |
| LOXIMVI | 5 | hr | p-p70S6K(T389) | 0.21672 | 1.93810 |
| LOXIMVI | 5 | hr | p-S6(S235/236) | 1.04020 | -0.28521 |
| LOXIMVI | 5 | hr | p-AMPK(T172) | -0.10043 | 1.10440 |
| LOXIMVI | 5 | hr | p-JNK(T183/Y185) | 0.17028 | 1.09670 |
| LOXIMVI | 5 | hr | Total c-Jun | 0.97660 | 0.51354 |
| LOXIMVI | 5 | hr | p-cJun(S63) | -1.07450 | 1.74440 |