PLSR model loadings (pMEK and pERK included) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20229)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| LOXIMVI | 5 | hr | p-P38(T180/Y182) | -0.13950 | 1.17940 |
| LOXIMVI | 5 | hr | p-HSP27(S82) | 0.17619 | 0.69578 |
| LOXIMVI | 5 | hr | p-NFKB(S536) | -0.20308 | 1.25910 |
| LOXIMVI | 5 | hr | Bim | 0.05776 | 1.61040 |
| LOXIMVI | 5 | hr | cPARP | 0.03754 | 1.22980 |
| LOXIMVI | 5 | hr | p-Histone H3(S10) | -0.16373 | 1.22900 |
| LOXIMVI | 5 | hr | p27 Kip1 | 0.60930 | 0.35230 |
| LOXIMVI | 10 | hr | pMEK(S217/221) | 1.48060 | -5.21470 |
| LOXIMVI | 10 | hr | pERK(T202/Y204) | 4.80110 | -1.91990 |
| LOXIMVI | 10 | hr | p-p90RSK(S380) | 1.13100 | -0.09360 |
| LOXIMVI | 10 | hr | p-p90RSK(T573) | 1.51060 | -0.21652 |
| LOXIMVI | 10 | hr | p-AKT(T308) | NaN | NaN |
| LOXIMVI | 10 | hr | p-AKT(S473) | 1.12730 | 0.24639 |
| LOXIMVI | 10 | hr | p-mTOR(S2448) | 1.56660 | -0.18706 |
| LOXIMVI | 10 | hr | p-p70S6K(T421/S424) | 2.34710 | -0.07531 |
| LOXIMVI | 10 | hr | p-p70S6K(T389) | 2.37070 | -0.07002 |
| LOXIMVI | 10 | hr | p-S6(S235/236) | 2.34170 | -1.08710 |
| LOXIMVI | 10 | hr | p-AMPK(T172) | 1.25840 | -0.09220 |
| LOXIMVI | 10 | hr | p-JNK(T183/Y185) | 1.52130 | 0.17262 |
| LOXIMVI | 10 | hr | Total c-Jun | 2.10780 | -0.47824 |
| LOXIMVI | 10 | hr | p-cJun(S63) | 0.56429 | 0.43862 |
| LOXIMVI | 10 | hr | p-P38(T180/Y182) | 2.21760 | -0.79864 |
| LOXIMVI | 10 | hr | p-HSP27(S82) | 1.19940 | -0.22674 |
| LOXIMVI | 10 | hr | p-NFKB(S536) | 1.07340 | 0.29559 |
| LOXIMVI | 10 | hr | Bim | 1.62650 | 0.28689 |