PLSR model loadings (pMEK and pERK included) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20229)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| C32 | 48 | hr | p-NFKB(S536) | 0.18830 | 0.73950 |
| C32 | 48 | hr | Bim | -2.68240 | -0.47847 |
| C32 | 48 | hr | cPARP | -2.89870 | -1.43150 |
| C32 | 48 | hr | p-Histone H3(S10) | 5.71940 | 1.28640 |
| C32 | 48 | hr | p27 Kip1 | -2.36070 | -0.94268 |
| COLO 858 | 1 | hr | pMEK(S217/221) | 3.82990 | 2.66990 |
| COLO 858 | 1 | hr | pERK(T202/Y204) | 12.50400 | -0.90222 |
| COLO 858 | 1 | hr | p-p90RSK(S380) | 0.47004 | 0.11736 |
| COLO 858 | 1 | hr | p-p90RSK(T573) | 0.62030 | -0.23203 |
| COLO 858 | 1 | hr | p-AKT(T308) | 1.17420 | -0.87423 |
| COLO 858 | 1 | hr | p-AKT(S473) | 0.69756 | -0.71854 |
| COLO 858 | 1 | hr | p-mTOR(S2448) | 0.77642 | -0.09959 |
| COLO 858 | 1 | hr | p-p70S6K(T421/S424) | 1.62610 | 0.13255 |
| COLO 858 | 1 | hr | p-p70S6K(T389) | 0.03065 | 0.40397 |
| COLO 858 | 1 | hr | p-S6(S235/236) | 2.22050 | -0.56086 |
| COLO 858 | 1 | hr | p-AMPK(T172) | 0.21348 | 0.11065 |
| COLO 858 | 1 | hr | p-JNK(T183/Y185) | 0.57658 | -0.03524 |
| COLO 858 | 1 | hr | Total c-Jun | 2.08940 | -0.11417 |
| COLO 858 | 1 | hr | p-cJun(S63) | 0.99136 | -0.42151 |
| COLO 858 | 1 | hr | p-P38(T180/Y182) | 3.30130 | 0.90980 |
| COLO 858 | 1 | hr | p-HSP27(S82) | 0.22950 | 0.02995 |
| COLO 858 | 1 | hr | p-NFKB(S536) | 0.75914 | -0.50125 |
| COLO 858 | 1 | hr | Bim | 2.01710 | -1.17000 |
| COLO 858 | 1 | hr | cPARP | 1.06030 | -0.72282 |
| COLO 858 | 1 | hr | p-Histone H3(S10) | 0.59000 | -0.69893 |