PLSR model loadings (pMEK and pERK included) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20229)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| COLO 858 | 1 | hr | p27 Kip1 | 0.63745 | 0.21879 |
| COLO 858 | 5 | hr | pMEK(S217/221) | 2.16380 | 1.40920 |
| COLO 858 | 5 | hr | pERK(T202/Y204) | 6.41020 | -2.35040 |
| COLO 858 | 5 | hr | p-p90RSK(S380) | -0.44924 | -0.68745 |
| COLO 858 | 5 | hr | p-p90RSK(T573) | -1.55450 | -1.09160 |
| COLO 858 | 5 | hr | p-AKT(T308) | -2.31750 | -1.28180 |
| COLO 858 | 5 | hr | p-AKT(S473) | -3.01000 | -1.17560 |
| COLO 858 | 5 | hr | p-mTOR(S2448) | -1.53260 | -1.13250 |
| COLO 858 | 5 | hr | p-p70S6K(T421/S424) | -1.01780 | -1.25000 |
| COLO 858 | 5 | hr | p-p70S6K(T389) | 1.04630 | -0.45845 |
| COLO 858 | 5 | hr | p-S6(S235/236) | 2.45650 | 0.20765 |
| COLO 858 | 5 | hr | p-AMPK(T172) | -0.81962 | -1.10390 |
| COLO 858 | 5 | hr | p-JNK(T183/Y185) | -1.51330 | -0.98711 |
| COLO 858 | 5 | hr | Total c-Jun | -0.12139 | -0.41216 |
| COLO 858 | 5 | hr | p-cJun(S63) | -0.71648 | -0.37460 |
| COLO 858 | 5 | hr | p-P38(T180/Y182) | -0.47735 | 0.95568 |
| COLO 858 | 5 | hr | p-HSP27(S82) | 0.08489 | -0.69765 |
| COLO 858 | 5 | hr | p-NFKB(S536) | -0.36829 | -0.24340 |
| COLO 858 | 5 | hr | Bim | -2.56010 | -1.58120 |
| COLO 858 | 5 | hr | cPARP | -1.73090 | -0.15150 |
| COLO 858 | 5 | hr | p-Histone H3(S10) | -1.59700 | -0.22481 |
| COLO 858 | 5 | hr | p27 Kip1 | -1.52820 | -1.37250 |
| COLO 858 | 10 | hr | pMEK(S217/221) | 4.40250 | 1.94370 |
| COLO 858 | 10 | hr | pERK(T202/Y204) | 12.92900 | -1.04130 |
| COLO 858 | 10 | hr | p-p90RSK(S380) | 0.92633 | -0.23783 |