PLSR model loadings (pMEK and pERK included) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20229)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| COLO 858 | 10 | hr | p-p90RSK(T573) | 0.51395 | -0.86021 |
| COLO 858 | 10 | hr | p-AKT(T308) | 0.57911 | -0.87183 |
| COLO 858 | 10 | hr | p-AKT(S473) | 0.23483 | -0.98610 |
| COLO 858 | 10 | hr | p-mTOR(S2448) | 0.83416 | -0.75395 |
| COLO 858 | 10 | hr | p-p70S6K(T421/S424) | 1.70800 | -0.85358 |
| COLO 858 | 10 | hr | p-p70S6K(T389) | 1.83820 | -0.01272 |
| COLO 858 | 10 | hr | p-S6(S235/236) | 7.34130 | 0.20442 |
| COLO 858 | 10 | hr | p-AMPK(T172) | 1.75930 | -0.34219 |
| COLO 858 | 10 | hr | p-JNK(T183/Y185) | 0.41111 | -0.50502 |
| COLO 858 | 10 | hr | Total c-Jun | 2.95680 | -0.12191 |
| COLO 858 | 10 | hr | p-cJun(S63) | 1.01350 | -0.38110 |
| COLO 858 | 10 | hr | p-P38(T180/Y182) | 2.62340 | 0.86053 |
| COLO 858 | 10 | hr | p-HSP27(S82) | 0.09046 | -0.22953 |
| COLO 858 | 10 | hr | p-NFKB(S536) | 2.47130 | -0.76557 |
| COLO 858 | 10 | hr | Bim | -0.23085 | -1.16470 |
| COLO 858 | 10 | hr | cPARP | 1.47780 | -0.42932 |
| COLO 858 | 10 | hr | p-Histone H3(S10) | 0.72294 | -0.45642 |
| COLO 858 | 10 | hr | p27 Kip1 | -0.44752 | -0.96292 |
| COLO 858 | 24 | hr | pMEK(S217/221) | 3.31280 | 1.63530 |
| COLO 858 | 24 | hr | pERK(T202/Y204) | 5.07030 | -1.90490 |
| COLO 858 | 24 | hr | p-p90RSK(S380) | -0.26238 | -0.25880 |
| COLO 858 | 24 | hr | p-p90RSK(T573) | -0.52574 | -0.62227 |
| COLO 858 | 24 | hr | p-AKT(T308) | -3.39600 | -0.51217 |
| COLO 858 | 24 | hr | p-AKT(S473) | -2.96270 | -0.36599 |
| COLO 858 | 24 | hr | p-mTOR(S2448) | -0.66628 | -0.73247 |