PLSR model loadings (pMEK and pERK included) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20229)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| SKMEL28 | 5 | hr | p-Histone H3(S10) | -0.95132 | 0.29938 |
| SKMEL28 | 5 | hr | p27 Kip1 | -0.94415 | 0.51126 |
| SKMEL28 | 10 | hr | pMEK(S217/221) | 5.73860 | -3.04210 |
| SKMEL28 | 10 | hr | pERK(T202/Y204) | 10.97700 | 0.61267 |
| SKMEL28 | 10 | hr | p-p90RSK(S380) | 2.05210 | 0.23962 |
| SKMEL28 | 10 | hr | p-p90RSK(T573) | 1.11590 | 0.49301 |
| SKMEL28 | 10 | hr | p-AKT(T308) | NaN | NaN |
| SKMEL28 | 10 | hr | p-AKT(S473) | 0.65185 | -0.51154 |
| SKMEL28 | 10 | hr | p-mTOR(S2448) | 0.99520 | -0.06486 |
| SKMEL28 | 10 | hr | p-p70S6K(T421/S424) | 1.03150 | -0.26741 |
| SKMEL28 | 10 | hr | p-p70S6K(T389) | 1.37810 | 0.06766 |
| SKMEL28 | 10 | hr | p-S6(S235/236) | 5.20700 | -0.01326 |
| SKMEL28 | 10 | hr | p-AMPK(T172) | 1.34750 | -0.49069 |
| SKMEL28 | 10 | hr | p-JNK(T183/Y185) | 1.57490 | -0.56841 |
| SKMEL28 | 10 | hr | Total c-Jun | 2.18140 | -0.34421 |
| SKMEL28 | 10 | hr | p-cJun(S63) | 0.81179 | -0.20458 |
| SKMEL28 | 10 | hr | p-P38(T180/Y182) | 0.44169 | -0.28344 |
| SKMEL28 | 10 | hr | p-HSP27(S82) | 0.78742 | -0.02509 |
| SKMEL28 | 10 | hr | p-NFKB(S536) | 1.73700 | 0.22572 |
| SKMEL28 | 10 | hr | Bim | -0.43873 | -0.07976 |
| SKMEL28 | 10 | hr | cPARP | 0.30410 | -0.02793 |
| SKMEL28 | 10 | hr | p-Histone H3(S10) | -0.04889 | 0.03547 |
| SKMEL28 | 10 | hr | p27 Kip1 | -0.35697 | -0.09583 |
| SKMEL28 | 24 | hr | pMEK(S217/221) | 3.88260 | -2.85530 |
| SKMEL28 | 24 | hr | pERK(T202/Y204) | 8.17010 | 1.62280 |