PLSR model loadings (pMEK and pERK included) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20229)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| WM1552C | 24 | hr | Bim | -1.52830 | -1.75270 |
| WM1552C | 24 | hr | cPARP | -0.19911 | -0.73071 |
| WM1552C | 24 | hr | p-Histone H3(S10) | 2.97420 | 0.30514 |
| WM1552C | 24 | hr | p27 Kip1 | 1.45800 | -0.49127 |
| WM1552C | 48 | hr | pMEK(S217/221) | 4.30530 | -1.39820 |
| WM1552C | 48 | hr | pERK(T202/Y204) | 6.52320 | 0.49083 |
| WM1552C | 48 | hr | p-p90RSK(S380) | 1.89770 | -0.21464 |
| WM1552C | 48 | hr | p-p90RSK(T573) | 0.94518 | -0.46261 |
| WM1552C | 48 | hr | p-AKT(T308) | 1.06580 | -0.35521 |
| WM1552C | 48 | hr | p-AKT(S473) | -0.78004 | -1.25180 |
| WM1552C | 48 | hr | p-mTOR(S2448) | 1.83510 | -0.47641 |
| WM1552C | 48 | hr | p-p70S6K(T421/S424) | 2.02220 | -0.69476 |
| WM1552C | 48 | hr | p-p70S6K(T389) | 2.07220 | -0.87907 |
| WM1552C | 48 | hr | p-S6(S235/236) | -0.20173 | -0.68676 |
| WM1552C | 48 | hr | p-AMPK(T172) | 1.32270 | -0.55608 |
| WM1552C | 48 | hr | p-JNK(T183/Y185) | 2.00940 | -0.29951 |
| WM1552C | 48 | hr | Total c-Jun | 1.10900 | -0.77966 |
| WM1552C | 48 | hr | p-cJun(S63) | -0.84384 | -1.24780 |
| WM1552C | 48 | hr | p-P38(T180/Y182) | 1.91730 | -0.39802 |
| WM1552C | 48 | hr | p-HSP27(S82) | 1.28990 | -0.55880 |
| WM1552C | 48 | hr | p-NFKB(S536) | 2.69370 | -0.11820 |
| WM1552C | 48 | hr | Bim | 0.90142 | -1.31470 |
| WM1552C | 48 | hr | cPARP | 2.24130 | -0.34061 |
| WM1552C | 48 | hr | p-Histone H3(S10) | 7.03180 | 1.41290 |
| WM1552C | 48 | hr | p27 Kip1 | 1.52600 | -0.65452 |