PLSR model loadings (pMEK and pERK included) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20229)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| WM1552C | 10 | hr | p-cJun(S63) | 1.71600 | -0.87250 |
| WM1552C | 10 | hr | p-P38(T180/Y182) | 0.62530 | -1.14460 |
| WM1552C | 10 | hr | p-HSP27(S82) | 0.67183 | -0.83648 |
| WM1552C | 10 | hr | p-NFKB(S536) | 0.69797 | -0.89830 |
| WM1552C | 10 | hr | Bim | 0.15272 | -1.73580 |
| WM1552C | 10 | hr | cPARP | 0.61577 | -1.16320 |
| WM1552C | 10 | hr | p-Histone H3(S10) | 0.47173 | -1.22090 |
| WM1552C | 10 | hr | p27 Kip1 | 2.16970 | -0.61342 |
| WM1552C | 24 | hr | pMEK(S217/221) | 3.16900 | -1.36050 |
| WM1552C | 24 | hr | pERK(T202/Y204) | 5.38850 | 0.61522 |
| WM1552C | 24 | hr | p-p90RSK(S380) | 0.08809 | -0.73320 |
| WM1552C | 24 | hr | p-p90RSK(T573) | -0.20617 | -0.65355 |
| WM1552C | 24 | hr | p-AKT(T308) | -0.86416 | -2.22510 |
| WM1552C | 24 | hr | p-AKT(S473) | -1.27900 | -1.08830 |
| WM1552C | 24 | hr | p-mTOR(S2448) | 0.34390 | -0.62883 |
| WM1552C | 24 | hr | p-p70S6K(T421/S424) | -0.14510 | -0.99657 |
| WM1552C | 24 | hr | p-p70S6K(T389) | -0.02337 | -1.06430 |
| WM1552C | 24 | hr | p-S6(S235/236) | -2.04100 | -0.76562 |
| WM1552C | 24 | hr | p-AMPK(T172) | -0.23900 | -0.81137 |
| WM1552C | 24 | hr | p-JNK(T183/Y185) | -0.05191 | -0.75282 |
| WM1552C | 24 | hr | Total c-Jun | 0.87431 | -0.56076 |
| WM1552C | 24 | hr | p-cJun(S63) | -1.35040 | -1.26080 |
| WM1552C | 24 | hr | p-P38(T180/Y182) | -0.26787 | -0.72097 |
| WM1552C | 24 | hr | p-HSP27(S82) | 0.35792 | -0.75630 |
| WM1552C | 24 | hr | p-NFKB(S536) | 0.81378 | -0.39216 |