Phosphorylation state and protein levels measured in BRAF(V600E/D) melanoma cell lines monitored by Reverse Phase Protein Arrays (RPPA) - Dataset (ID:20218)

August 25, 2015: The data file for this dataset was updated to include additional DMSO control data that were inadvertently omitted from the original version. The Assay Protocol description of how experimental data were normalized to DMSO control data also was clarified (point 9).

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Small Molecule Cell Line Drug Concentration Conc Unit Time Point Time Point Unit Replicate Scanner/Software pMEK(S217/221) Normalized Median pMEK(S217/221) pERK(T202/Y204) Normalized Median pERK(T202/Y204) p-p90RSK(S380) Normalized Median p-p90RSK(S380) p-p90RSK(T573) Normalized Median p-p90RSK(T573) p-AKT(T308) Normalized Median p-AKT(T308) p-AKT(S473) Normalized Median p-AKT(S473) p-mTOR(S2448) Normalized Median p-mTOR(S2448) p-p70S6K(T421/S424) Normalized Median p-p70S6K(T421/S424) p-p70S6K(T389) Normalized Median p-p70S6K(T389) p-S6(S235/236) Normalized Median p-S6(S235/236) p-AMPK(T172) Normalized Median p-AMPK(T172) p-JNK(T183/Y185) Normalized Median p-JNK(T183/Y185) Total c-Jun Normalized Median Total c-Jun p-cJun(S63) Normalized Median p-cJun(S63) p-P38(T180/Y182) Normalized Median p-P38(T180/Y182) p-HSP27(S82) Normalized Median p-HSP27(S82) p-NFKB(S536) Normalized Median p-NFKB(S536) Bim Normalized Median Bim cPARP Normalized Median cPARP p-Histone H3(S10) Normalized Median p-Histone H3(S10) p27 Kip1 Normalized Median p27 Kip1
LOXIMVI 0.0000
uM
 10
hr
 3
InnoScan/Mapix
 0.1072 0.4854 0.1294 0.0168 0.0154 0.0442 0.0072 0.0135 0.8929 0.0288 0.0629 0.4082 0.0380 0.0503 0.0051 0.0793 0.0232 0.0103 0.3195 0.1024
LOXIMVI 0.0000
uM
 10
hr
 3
InnoScan/Mapix
 0.0753 0.2916 0.0873 0.0231 0.0135 0.0319 0.0031 0.0060 0.7752 0.0138 0.0423 0.2732 0.0245 0.0225 0.0040 0.0554 0.0132 0.0088 0.2347 0.0976
LOXIMVI 0.0000
uM
 10
hr
 3
InnoScan/Mapix
 0.0730 0.2793 0.0840 0.0152 0.0135 0.0309 0.0041 0.0090 0.6410 0.0147 0.0397 0.2674 0.0247 0.0289 0.0051 0.0613 0.0220 0.0078 0.2198 0.0917
LOXIMVI 0.0000
uM
 10
hr
 3
InnoScan/Mapix
 0.1052 0.4608 0.1148 0.0169 0.0160 0.0420 0.0043 0.0081 0.9901 0.0265 0.0587 0.3718 0.0399 0.0431 0.0050 0.0631 0.0186 0.0125 0.3413 0.1395
LOXIMVI 0.0000
uM
 10
hr
 3
InnoScan/Mapix
 0.1074 0.4202 0.1099 0.0210 0.0142 0.0359 0.0053 0.0110 0.9091 0.0246 0.0559 0.3472 0.0352 0.0433 0.0060 0.0676 0.0196 0.0091 0.3195 0.1053
LOXIMVI 0.0000
uM
 10
hr
 3
InnoScan/Mapix
 0.0835 0.2591 0.0642 0.0135 0.0117 0.0360 0.0027 0.0057 0.7299 0.0184 0.0295 0.3049 0.0326 0.0297 0.0033 0.0631 0.0107 0.0075 0.2416 0.1144
LOXIMVI 0.0000
uM
 10
hr
 3
InnoScan/Mapix
 0.0927 0.2227 0.0678 0.0131 0.0158 0.0347 0.0045 0.0078 0.5405 0.0193 0.0345 0.3448 0.0461 0.0460 0.0058 0.0709 0.0179 0.0077 0.1901 0.1015
LOXIMVI 0.0000
uM
 10
hr
 4
InnoScan/Mapix
 0.0879 0.2967 0.1092 0.0183 0.0162 0.0389 0.0034 0.0098 1.1905 0.0144 0.0403 0.3831 0.0326 0.0259 0.0040 0.0697 0.0141 0.0096 0.3125 0.1587
LOXIMVI 0.0000
uM
 10
hr
 4
InnoScan/Mapix
 0.0953 0.3484 0.1056 0.0151 0.0146 0.0309 0.0047 0.0118 0.9709 0.0145 0.0445 0.3300 0.0301 0.0369 0.0048 0.0641 0.0177 0.0099 0.2907 0.0892
LOXIMVI 0.0000
uM
 10
hr
 4
InnoScan/Mapix
 0.0912 0.2445 0.0659 0.0125 0.0253 0.0352 0.0029 0.0056 0.7692 0.0114 0.0424 0.3663 0.0328 0.0302 0.0038 0.0615 0.0119 0.0072 0.2387 0.1748
LOXIMVI 0.0000
uM
 10
hr
 4
InnoScan/Mapix
 0.0980 0.1972 0.0696 0.0106 0.0192 0.0291 0.0040 0.0109 0.6098 0.0306 0.0299 0.3356 0.0274 0.0263 0.0043 0.0614 0.0151 0.0074 0.2262 0.0978
LOXIMVI 0.0000
uM
 10
hr
 4
InnoScan/Mapix
 0.1110 0.4386 0.1294 0.0192 0.0185 0.0428 0.0046 0.0089 1.2048 0.0237 0.0646 0.0461 0.0467 0.0091 0.0734 0.0206 0.0133 0.3774 0.1704
LOXIMVI 0.0000
uM
 10
hr
 4
InnoScan/Mapix
 0.1211 0.3922 0.1241 0.0173 0.0173 0.0339 0.0055 0.0125 0.9901 0.0235 0.0620 0.3876 0.0367 0.0420 0.0076 0.0726 0.0242 0.0132 0.3745 0.0962
LOXIMVI 0.0000
uM
 10
hr
 4
InnoScan/Mapix
 0.0913 0.2066 0.0646 0.0124 0.0229 0.0310 0.0042 0.0057 0.8265 0.0156 0.0309 0.3460 0.0370 0.0390 0.0037 0.0598 0.0124 0.0081 0.2222 0.1064
LOXIMVI 0.0000
uM
 10
hr
 4
InnoScan/Mapix
 0.0956 0.2174 0.0626 0.0120 0.0124 0.0274 0.0052 0.0126 0.5291 0.0144 0.0340 0.3247 0.0300 0.0281 0.0055 0.0660 0.0173 0.0087 0.2532 0.0961
LOXIMVI 0.0000
uM
 10
hr
 5
InnoScan/Mapix
 0.1208 0.4329 0.1253 0.0169 0.0170 0.0573 0.0059 0.0111 0.8850 0.0233 0.0676 0.4444 0.0425 0.0344 0.0065 0.0746 0.0256 0.0121 0.3413 0.2193
LOXIMVI 0.0000
uM
 10
hr
 5
InnoScan/Mapix
 0.1284 0.4505 0.1304 0.0182 0.0273 0.0512 0.0057 0.0136 0.8065 0.0272 0.0672 0.4065 0.0397 0.0387 0.0074 0.0743 0.0271 0.0128 0.2899 0.1407
LOXIMVI 0.0000
uM
 10
hr
 5
InnoScan/Mapix
 0.1119 0.2865 0.0987 0.0149 0.0239 0.0390 0.0045 0.0088 0.8696 0.0160 0.0495 0.3378 0.0208 0.0051 0.0778 0.0207 0.0104 0.3012 0.1357
LOXIMVI 0.0000
uM
 10
hr
 5
InnoScan/Mapix
 0.1020 0.2933 0.1109 0.0143 0.0265 0.0384 0.0037 0.0135 0.9901 0.0161 0.0489 0.3460 0.0398 0.0203 0.0086 0.0775 0.0227 0.0097 0.2809 0.1037
LOXIMVI 0.0000
uM
 10
hr
 5
InnoScan/Mapix
 0.1166 0.3650 0.1100 0.0164 0.0136 0.0442 0.0049 0.0080 0.9091 0.0241 0.0596 0.3906 0.0385 0.0309 0.0071 0.0700 0.0199 0.0110 0.3215 0.1575
LOXIMVI 0.0000
uM
 10
hr
 5
InnoScan/Mapix
 0.1224 0.3559 0.1188 0.0143 0.0158 0.0364 0.0047 0.0113 1.0000 0.0260 0.0620 0.3745 0.0377 0.0326 0.0082 0.0696 0.0199 0.0114 0.2762 0.1133
LOXIMVI 0.0000
uM
 10
hr
 5
InnoScan/Mapix
 0.1030 0.2016 0.0703 0.0110 0.0105 0.0393 0.0040 0.0071 0.7519 0.0172 0.0378 0.3650 0.0407 0.0265 0.0049 0.0654 0.0178 0.0094 0.2732 0.2227
LOXIMVI 0.0000
uM
 10
hr
 5
InnoScan/Mapix
 0.1002 0.2242 0.0641 0.0112 0.0240 0.0326 0.0047 0.0103 0.6623 0.0172 0.0338 0.4444 0.0369 0.0305 0.0051 0.0682 0.0157 0.0087 0.2488 0.1748
LOXIMVI 0.0000
uM
 10
hr
 6
InnoScan/Mapix
 0.0993 0.4082 0.1179 0.0136 0.0159 0.0430 0.0044 0.0083 0.8130 0.0190 0.0584 0.3584 0.0347 0.0240 0.0058 0.0207 0.3205
LOXIMVI 0.0000
uM
 10
hr
 6
InnoScan/Mapix
 0.0918 0.3846 0.1196 0.0194 0.0154 0.0402 0.0043 0.0084 0.8333 0.0182 0.0565 0.3367 0.0332 0.0253 0.0052 0.0628 0.0206 0.0092 0.2457 0.0958