HMS LINCS Project

Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)

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Small molecules	Cells
10057:MK2206 10098:Gefitinib 10172:GSK1059615 10232:Dactolisib 10280:Triciribine 10345:Torkinib	50091:AU565 50213:HCC1954 50541:T47D 50583:MCF 10A

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Small Molecule	Cell Line	Drug Concentration	Conc Units	Timepoint	Timepoint Units	Measured pERK (Alexa 488)	Measured p-Rb (Alexa 568)	Alexa Fluor 647	Measured p-Akt/p-4EBP1/p-S6 (Alexa 647)	Image
GSK1059615	HCC1954	10.0	nM	6	hr	469.32	101.00	p-Akt	64.80
GSK1059615	HCC1954	10.0	nM	24	hr	354.94	111.51	p-Akt	64.33
MK2206	HCC1954	10.0	nM	6	hr	282.65	82.14	p-Akt	25.78
MK2206	HCC1954	10.0	nM	24	hr	302.34	113.64	p-Akt	47.58
Triciribine	HCC1954	10.0	nM	6	hr	236.96	79.74	p-Akt	39.32
Triciribine	HCC1954	10.0	nM	24	hr	290.45	102.11	p-Akt	53.04
Dactolisib	HCC1954	10.0	nM	6	hr	192.04	59.35	p-Akt	27.50
Dactolisib	HCC1954	10.0	nM	24	hr	259.87	90.98	p-Akt	60.69
Gefitinib	MCF 10A	10.0	nM	6	hr	407.34	172.62	p-Akt	42.11
Gefitinib	MCF 10A	10.0	nM	24	hr	322.66	158.49	p-Akt	38.54
Torkinib	MCF 10A	1.78	nM	6	hr	458.96	166.90	p-Akt	40.68
Torkinib	MCF 10A	1.78	nM	24	hr	344.89	145.25	p-Akt	35.23
GSK1059615	MCF 10A	10.0	nM	6	hr	416.96	171.76	p-Akt	38.13
GSK1059615	MCF 10A	10.0	nM	24	hr	306.91	140.32	p-Akt	31.96
MK2206	MCF 10A	10.0	nM	6	hr	379.78	154.15	p-Akt	32.94
MK2206	MCF 10A	10.0	nM	24	hr	298.59	144.01	p-Akt	29.48
Triciribine	MCF 10A	10.0	nM	6	hr	380.71	155.18	p-Akt	33.02
Triciribine	MCF 10A	10.0	nM	24	hr	252.44	141.63	p-Akt	25.75
Dactolisib	MCF 10A	10.0	nM	6	hr	346.24	150.32	p-Akt	33.45
Dactolisib	MCF 10A	10.0	nM	24	hr	239.96	138.65	p-Akt	26.46
Gefitinib	T47D	10.0	nM	6	hr	179.23	94.94	p-Akt	102.93
Gefitinib	T47D	10.0	nM	24	hr	165.83	104.92	p-Akt	78.43
Torkinib	T47D	1.78	nM	6	hr	176.33	81.25	p-Akt	63.03
Torkinib	T47D	1.78	nM	24	hr	158.31	90.25	p-Akt	46.79
GSK1059615	T47D	10.0	nM	6	hr	162.70	85.51	p-Akt	87.75

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