Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| MK2206 | AU565 | 3.16 | uM | 6 | hr | 304.34 | 68.30 | p-S6 | 77.10 | |
| MK2206 | AU565 | 3.16 | uM | 24 | hr | 347.69 | 71.65 | p-S6 | 89.49 | |
| Triciribine | AU565 | 3.16 | uM | 6 | hr | 336.27 | 82.81 | p-S6 | 145.60 | |
| Triciribine | AU565 | 3.16 | uM | 24 | hr | 499.78 | 85.57 | p-S6 | 194.59 | |
| Dactolisib | AU565 | 3.16 | uM | 6 | hr | 198.70 | 40.41 | p-S6 | 11.18 | |
| Dactolisib | AU565 | 3.16 | uM | 24 | hr | 496.60 | 68.46 | p-S6 | 12.60 | |
| Gefitinib | HCC1954 | 3.16 | uM | 6 | hr | 138.54 | 52.42 | p-S6 | 83.69 | |
| Gefitinib | HCC1954 | 3.16 | uM | 24 | hr | 261.94 | 88.85 | p-S6 | 352.30 | |
| Torkinib | HCC1954 | 2.37 | uM | 6 | hr | 143.76 | 24.81 | p-S6 | 9.70 | |
| Torkinib | HCC1954 | 2.37 | uM | 24 | hr | 241.12 | 64.31 | p-S6 | 9.33 | |
| GSK1059615 | HCC1954 | 3.16 | uM | 6 | hr | 424.45 | 74.02 | p-S6 | 10.87 | |
| GSK1059615 | HCC1954 | 3.16 | uM | 24 | hr | 265.29 | 58.34 | p-S6 | 8.29 | |
| MK2206 | HCC1954 | 3.16 | uM | 6 | hr | 277.51 | 79.67 | p-S6 | 315.96 | |
| MK2206 | HCC1954 | 3.16 | uM | 24 | hr | 318.38 | 98.62 | p-S6 | 315.85 | |
| Triciribine | HCC1954 | 3.16 | uM | 6 | hr | 296.11 | 94.58 | p-S6 | 589.19 | |
| Triciribine | HCC1954 | 3.16 | uM | 24 | hr | 220.30 | 93.53 | p-S6 | 329.75 | |
| Dactolisib | HCC1954 | 3.16 | uM | 6 | hr | 231.49 | 70.49 | p-S6 | 12.72 | |
| Dactolisib | HCC1954 | 3.16 | uM | 24 | hr | 267.00 | 64.16 | p-S6 | 8.95 | |
| Gefitinib | MCF 10A | 3.16 | uM | 6 | hr | 186.15 | 141.97 | p-S6 | 403.58 | |
| Gefitinib | MCF 10A | 3.16 | uM | 24 | hr | 223.18 | 38.43 | p-S6 | 75.40 | |
| Torkinib | MCF 10A | 2.37 | uM | 6 | hr | 592.05 | 142.99 | p-S6 | 474.15 | |
| Torkinib | MCF 10A | 2.37 | uM | 24 | hr | 472.27 | 75.38 | p-S6 | 284.40 | |
| GSK1059615 | MCF 10A | 3.16 | uM | 6 | hr | 216.21 | 121.05 | p-S6 | 12.53 | |
| GSK1059615 | MCF 10A | 3.16 | uM | 24 | hr | 225.10 | 112.78 | p-S6 | 13.32 | |
| MK2206 | MCF 10A | 3.16 | uM | 6 | hr | 371.59 | 146.22 | p-S6 | 525.20 | |