HMS LINCS Project

Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)

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Small molecules	Cells
10057:MK2206 10098:Gefitinib 10172:GSK1059615 10232:Dactolisib 10280:Triciribine 10345:Torkinib	50091:AU565 50213:HCC1954 50541:T47D 50583:MCF 10A

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Small Molecule	Cell Line	Drug Concentration	Conc Units	Timepoint	Timepoint Units	Measured pERK (Alexa 488)	Measured p-Rb (Alexa 568)	Alexa Fluor 647	Measured p-Akt/p-4EBP1/p-S6 (Alexa 647)	Image
GSK1059615	T47D	10.0	nM	24	hr	160.21	92.33	p-Akt	59.32
MK2206	T47D	10.0	nM	6	hr	94.04	32.48	p-Akt	9.35
MK2206	T47D	10.0	nM	24	hr	156.26	91.80	p-Akt	37.50
Triciribine	T47D	10.0	nM	6	hr	105.56	58.87	p-Akt	19.98
Triciribine	T47D	10.0	nM	24	hr	168.74	97.33	p-Akt	59.12
Dactolisib	T47D	10.0	nM	6	hr	105.88	55.02	p-Akt	13.40
Dactolisib	T47D	10.0	nM	24	hr	140.23	84.77	p-Akt	33.74
Gefitinib	AU565	31.6	nM	6	hr	286.23	60.88	p-Akt	29.80
Gefitinib	AU565	31.6	nM	24	hr	529.81	117.15	p-Akt	139.91
Torkinib	AU565	7.5	nM	6	hr	240.99	44.76	p-Akt	15.24
Torkinib	AU565	7.5	nM	24	hr	441.84	88.60	p-Akt	51.74
GSK1059615	AU565	31.6	nM	6	hr	274.09	69.05	p-Akt	27.94
GSK1059615	AU565	31.6	nM	24	hr	500.89	114.20	p-Akt	81.59
MK2206	AU565	31.6	nM	6	hr	395.87	81.88	p-Akt	27.47
MK2206	AU565	31.6	nM	24	hr	401.33	107.98	p-Akt	41.61
Triciribine	AU565	31.6	nM	6	hr	286.47	69.09	p-Akt	20.40
Triciribine	AU565	31.6	nM	24	hr	529.95	113.46	p-Akt	82.44
Dactolisib	AU565	31.6	nM	6	hr	198.09	39.02	p-Akt	14.31
Dactolisib	AU565	31.6	nM	24	hr	459.58	74.34	p-Akt	46.97
Gefitinib	HCC1954	31.6	nM	6	hr	188.14	53.26	p-Akt	25.31
Gefitinib	HCC1954	31.6	nM	24	hr	282.36	116.35	p-Akt	78.62
Torkinib	HCC1954	7.5	nM	6	hr	189.93	35.55	p-Akt	16.14
Torkinib	HCC1954	7.5	nM	24	hr	283.38	100.32	p-Akt	46.18
GSK1059615	HCC1954	31.6	nM	6	hr	453.20	97.17	p-Akt	46.95
GSK1059615	HCC1954	31.6	nM	24	hr	303.54	102.79	p-Akt	53.54

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