Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Torkinib | MCF 10A | 2.37 | uM | 6 | hr | 620.84 | 155.04 | p-Akt | 19.11 | |
| Torkinib | MCF 10A | 2.37 | uM | 24 | hr | 450.70 | 63.76 | p-Akt | 11.66 | |
| GSK1059615 | MCF 10A | 3.16 | uM | 6 | hr | 223.50 | 118.52 | p-Akt | 14.58 | |
| GSK1059615 | MCF 10A | 3.16 | uM | 24 | hr | 220.43 | 104.70 | p-Akt | 17.25 | |
| MK2206 | MCF 10A | 3.16 | uM | 6 | hr | 362.90 | 136.60 | p-Akt | 34.88 | |
| MK2206 | MCF 10A | 3.16 | uM | 24 | hr | 339.83 | 147.32 | p-Akt | 14.25 | |
| Triciribine | MCF 10A | 3.16 | uM | 6 | hr | 368.60 | 138.28 | p-Akt | 42.99 | |
| Triciribine | MCF 10A | 3.16 | uM | 24 | hr | 291.55 | 118.36 | p-Akt | 17.80 | |
| Dactolisib | MCF 10A | 3.16 | uM | 6 | hr | 279.99 | 117.79 | p-Akt | 15.56 | |
| Dactolisib | MCF 10A | 3.16 | uM | 24 | hr | 347.40 | 68.81 | p-Akt | 13.92 | |
| Gefitinib | T47D | 3.16 | uM | 6 | hr | 156.73 | 93.87 | p-Akt | 103.83 | |
| Gefitinib | T47D | 3.16 | uM | 24 | hr | 144.01 | 83.55 | p-Akt | 67.99 | |
| Torkinib | T47D | 2.37 | uM | 6 | hr | 145.64 | 70.16 | p-Akt | 14.84 | |
| Torkinib | T47D | 2.37 | uM | 24 | hr | 128.17 | 38.84 | p-Akt | 13.90 | |
| GSK1059615 | T47D | 3.16 | uM | 6 | hr | 169.45 | 61.91 | p-Akt | 15.84 | |
| GSK1059615 | T47D | 3.16 | uM | 24 | hr | 211.52 | 65.88 | p-Akt | 20.20 | |
| MK2206 | T47D | 3.16 | uM | 6 | hr | 102.31 | 29.14 | p-Akt | 5.87 | |
| MK2206 | T47D | 3.16 | uM | 24 | hr | 150.54 | 44.09 | p-Akt | 14.26 | |
| Triciribine | T47D | 3.16 | uM | 6 | hr | 103.46 | 24.67 | p-Akt | 8.36 | |
| Triciribine | T47D | 3.16 | uM | 24 | hr | 173.42 | 66.40 | p-Akt | 35.63 | |
| Dactolisib | T47D | 3.16 | uM | 6 | hr | 94.75 | 44.06 | p-Akt | 6.83 | |
| Dactolisib | T47D | 3.16 | uM | 24 | hr | 132.13 | 45.78 | p-Akt | 14.01 | |
| Gefitinib | AU565 | 10.0 | uM | 6 | hr | 292.18 | 65.87 | p-Akt | 21.37 | |
| Gefitinib | AU565 | 10.0 | uM | 24 | hr | 347.54 | 73.63 | p-Akt | 25.17 | |
| Torkinib | AU565 | 10.0 | uM | 6 | hr | 310.33 | 55.05 | p-Akt | 15.34 | |