Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Dactolisib | MCF 10A | 1.0 | uM | 6 | hr | 304.54 | 120.52 | p-4EBP1 | 7.16 | |
| Dactolisib | MCF 10A | 1.0 | uM | 24 | hr | 358.30 | 52.88 | p-4EBP1 | 6.29 | |
| Gefitinib | T47D | 1.0 | uM | 6 | hr | 151.66 | 97.78 | p-4EBP1 | 485.17 | |
| Gefitinib | T47D | 1.0 | uM | 24 | hr | 136.33 | 105.43 | p-4EBP1 | 377.18 | |
| Torkinib | T47D | 562.0 | nM | 6 | hr | 152.94 | 72.02 | p-4EBP1 | 40.14 | |
| Torkinib | T47D | 562.0 | nM | 24 | hr | 115.44 | 42.33 | p-4EBP1 | 28.85 | |
| GSK1059615 | T47D | 1.0 | uM | 6 | hr | 154.32 | 62.44 | p-4EBP1 | 362.13 | |
| GSK1059615 | T47D | 1.0 | uM | 24 | hr | 142.01 | 52.25 | p-4EBP1 | 256.14 | |
| MK2206 | T47D | 1.0 | uM | 6 | hr | 95.85 | 36.68 | p-4EBP1 | 87.19 | |
| MK2206 | T47D | 1.0 | uM | 24 | hr | 139.84 | 56.58 | p-4EBP1 | 292.80 | |
| Triciribine | T47D | 1.0 | uM | 6 | hr | 125.28 | 64.49 | p-4EBP1 | 226.10 | |
| Triciribine | T47D | 1.0 | uM | 24 | hr | 159.21 | 77.45 | p-4EBP1 | 335.03 | |
| Dactolisib | T47D | 1.0 | uM | 6 | hr | 88.97 | 38.37 | p-4EBP1 | 6.28 | |
| Dactolisib | T47D | 1.0 | uM | 24 | hr | 116.02 | 40.65 | p-4EBP1 | 10.71 | |
| Gefitinib | AU565 | 3.16 | uM | 6 | hr | 218.57 | 50.64 | p-4EBP1 | 58.44 | |
| Gefitinib | AU565 | 3.16 | uM | 24 | hr | 334.61 | 83.12 | p-4EBP1 | 116.04 | |
| Torkinib | AU565 | 2.37 | uM | 6 | hr | 219.64 | 36.57 | p-4EBP1 | 7.15 | |
| Torkinib | AU565 | 2.37 | uM | 24 | hr | 414.42 | 67.36 | p-4EBP1 | 11.18 | |
| GSK1059615 | AU565 | 3.16 | uM | 6 | hr | 226.42 | 50.58 | p-4EBP1 | 29.60 | |
| GSK1059615 | AU565 | 3.16 | uM | 24 | hr | 357.44 | 84.22 | p-4EBP1 | 35.21 | |
| MK2206 | AU565 | 3.16 | uM | 6 | hr | 343.27 | 71.17 | p-4EBP1 | 102.55 | |
| MK2206 | AU565 | 3.16 | uM | 24 | hr | 344.94 | 75.13 | p-4EBP1 | 102.38 | |
| Triciribine | AU565 | 3.16 | uM | 6 | hr | 287.03 | 70.34 | p-4EBP1 | 75.61 | |
| Triciribine | AU565 | 3.16 | uM | 24 | hr | 407.60 | 78.72 | p-4EBP1 | 102.21 | |
| Dactolisib | AU565 | 3.16 | uM | 6 | hr | 229.05 | 49.42 | p-4EBP1 | 8.25 | |