Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Triciribine | T47D | 3.16 | nM | 6 | hr | 108.85 | 68.27 | p-S6 | 121.84 | |
| Triciribine | T47D | 3.16 | nM | 24 | hr | 152.67 | 103.52 | p-S6 | 378.65 | |
| Dactolisib | T47D | 3.16 | nM | 6 | hr | 94.68 | 57.90 | p-S6 | 78.09 | |
| Dactolisib | T47D | 3.16 | nM | 24 | hr | 140.91 | 100.68 | p-S6 | 293.18 | |
| Gefitinib | AU565 | 10.0 | nM | 6 | hr | 269.00 | 63.11 | p-S6 | 144.00 | |
| Gefitinib | AU565 | 10.0 | nM | 24 | hr | 572.61 | 129.37 | p-S6 | 514.02 | |
| Torkinib | AU565 | 1.78 | nM | 6 | hr | 295.53 | 59.13 | p-S6 | 84.79 | |
| Torkinib | AU565 | 1.78 | nM | 24 | hr | 467.41 | 115.26 | p-S6 | 364.30 | |
| GSK1059615 | AU565 | 10.0 | nM | 6 | hr | 301.45 | 75.95 | p-S6 | 168.82 | |
| GSK1059615 | AU565 | 10.0 | nM | 24 | hr | 471.15 | 122.60 | p-S6 | 531.80 | |
| MK2206 | AU565 | 10.0 | nM | 6 | hr | 352.21 | 85.33 | p-S6 | 323.62 | |
| MK2206 | AU565 | 10.0 | nM | 24 | hr | 403.39 | 122.90 | p-S6 | 495.64 | |
| Triciribine | AU565 | 10.0 | nM | 6 | hr | 315.95 | 83.88 | p-S6 | 198.48 | |
| Triciribine | AU565 | 10.0 | nM | 24 | hr | 550.75 | 128.39 | p-S6 | 471.06 | |
| Dactolisib | AU565 | 10.0 | nM | 6 | hr | 253.74 | 54.25 | p-S6 | 31.15 | |
| Dactolisib | AU565 | 10.0 | nM | 24 | hr | 494.50 | 95.11 | p-S6 | 83.07 | |
| Gefitinib | HCC1954 | 10.0 | nM | 6 | hr | 188.28 | 51.03 | p-S6 | 92.88 | |
| Gefitinib | HCC1954 | 10.0 | nM | 24 | hr | 288.96 | 126.31 | p-S6 | 295.16 | |
| Torkinib | HCC1954 | 1.78 | nM | 6 | hr | 177.69 | 45.58 | p-S6 | 95.84 | |
| Torkinib | HCC1954 | 1.78 | nM | 24 | hr | 255.05 | 108.46 | p-S6 | 347.44 | |
| GSK1059615 | HCC1954 | 10.0 | nM | 6 | hr | 375.08 | 92.24 | p-S6 | 317.73 | |
| GSK1059615 | HCC1954 | 10.0 | nM | 24 | hr | 294.27 | 111.75 | p-S6 | 307.85 | |
| MK2206 | HCC1954 | 10.0 | nM | 6 | hr | 274.54 | 81.59 | p-S6 | 252.76 | |
| MK2206 | HCC1954 | 10.0 | nM | 24 | hr | 277.31 | 118.99 | p-S6 | 291.60 | |
| Triciribine | HCC1954 | 10.0 | nM | 6 | hr | 171.71 | 58.26 | p-S6 | 154.86 | |