Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Fascaplysin | MCF12A | -4.4776 | 0.9884 | -6.3991 | -6.3982 | -6.4850 | 2.1690 | 0.0017 | 0.0024 | 5.7422 |
| Fascaplysin | MX1 | -4.4776 | 0.9772 | -6.4086 | -6.4082 | -6.5484 | 3.6930 | 0.0036 | 0.0036 | 5.4928 |
| Fascaplysin | T47DKBLUC | -4.4776 | 0.9903 | -7.1796 | -7.1786 | -7.3774 | 2.5360 | 0.0036 | 0.0036 | 4.5486 |
| Fascaplysin | 600MPE | -4.4776 | 0.9843 | -6.4026 | -6.4010 | -6.5333 | 3.9995 | 0.0053 | 0.0053 | 5.6846 |
| Fascaplysin | HCC2185 | -4.4776 | 0.9710 | -6.4916 | -6.4913 | -6.8490 | 1.8110 | 0.0000 | 0.0002 | 5.3366 |
| Fascaplysin | HCC3153 | -4.4776 | 0.9915 | -6.3846 | -6.3845 | -6.6083 | 2.0430 | 0.0007 | 0.0010 | 5.6496 |
| Fascaplysin | LY2 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| Fascaplysin | ZR75B | -4.4776 | 0.9810 | -6.3476 | -6.3463 | -6.4454 | 2.7840 | 0.0030 | 0.0030 | 5.7017 |
| Gemcitabine | MCF7 | -3.8416 | 0.7667 | -8.0196 | -3.8416 | -4.4890 | 2.3040 | 0.7316 | 0.7319 | 7.3115 |
| Gemcitabine | SK-BR-3 | -3.8416 | 0.9240 | -7.9446 | -5.8528 | -7.9490 | 3.9990 | 0.4263 | 0.4263 | 5.4749 |
| Gemcitabine | MDA-MB-231 | -3.8416 | 0.9334 | -7.9971 | -7.1523 | -7.5536 | 1.4703 | 0.4295 | 0.4311 | 5.4652 |
| Gemcitabine | AU565 | -3.8416 | 0.9938 | -7.7556 | -7.6986 | -7.8877 | 2.5020 | 0.1406 | 0.1406 | 3.7074 |
| Gemcitabine | BT-20 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| Gemcitabine | BT-474 | -3.8416 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | 8.1726 |
| Gemcitabine | BT-483 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| Gemcitabine | BT-549 | -3.8416 | 0.9956 | -8.0476 | -7.9848 | -8.0901 | 1.7390 | 0.1050 | 0.1050 | 3.1948 |
| Gemcitabine | CAMA-1 | -3.8416 | 0.8152 | -7.2376 | -3.8416 | -6.5058 | 0.5254 | 0.6609 | 0.6664 | 7.2283 |
| Gemcitabine | HCC1143 | -3.8416 | 0.9031 | -8.1686 | -3.8416 | -8.1737 | 3.9960 | 0.5155 | 0.5155 | 5.9323 |
| Gemcitabine | HCC1395 | -3.8416 | 0.8728 | -6.5846 | -3.8416 | -6.5152 | 0.6857 | 0.5879 | 0.5974 | 7.2072 |
| Gemcitabine | HCC1419 | -3.8416 | 0.7119 | -7.3646 | -3.8416 | -6.5238 | 0.8363 | 0.8120 | 0.8122 | 8.1875 |
| Gemcitabine | HCC1428 | -3.8416 | 0.8697 | -4.6041 | -3.8416 | -4.4875 | 4.0000 | 0.7348 | 0.7350 | 8.5577 |
| Gemcitabine | HCC1569 | -3.8416 | 0.8660 | -7.1526 | -4.5744 | -6.0004 | 0.4363 | 0.5148 | 0.5326 | 6.4818 |
| Gemcitabine | HCC1806 | -3.8416 | 0.9790 | -8.6516 | -8.5897 | -8.7366 | 2.1030 | 0.1252 | 0.1252 | 2.5814 |
| Gemcitabine | HCC1937 | -3.8416 | 0.9065 | -6.4476 | -3.8727 | -6.1325 | 0.3636 | 0.4421 | 0.4987 | 6.6081 |
| Gemcitabine | HCC1954 | -3.8416 | 0.7528 | -7.9646 | -3.8416 | -3.8416 | 0.8621 | 0.7267 | 0.7268 | 7.2829 |