Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Valproic acid | SUM229PE | -1.8239 | 0.9137 | -2.5827 | -2.5826 | -2.6931 | 1.5890 | 0.0000 | 0.0586 | 7.0407 |
| Valproic acid | SUM52PE | -1.8239 | 0.9597 | -2.6659 | -2.6657 | -2.9162 | 1.5750 | 0.0000 | 0.0452 | 7.4548 |
| Valproic acid | 184A1 | -1.8239 | 0.9537 | -2.5703 | -2.5703 | -3.0147 | 0.7775 | 0.0000 | 0.2081 | 7.2682 |
| Valproic acid | MCF12A | -1.8239 | 0.9575 | -2.6011 | -2.6010 | -2.7737 | 1.3295 | 0.0000 | 0.0857 | 7.0760 |
| Valproic acid | MX1 | -1.8239 | 0.9515 | -2.9369 | -2.9367 | -3.4290 | 1.4100 | 0.0000 | 0.0266 | 6.5536 |
| Valproic acid | T47DKBLUC | -1.8239 | 0.9707 | -2.4693 | -2.4694 | -2.7858 | 1.6510 | 0.0000 | 0.0792 | 7.4323 |
| Valproic acid | 600MPE | -1.8239 | 0.9019 | -2.1659 | -1.8239 | -2.5107 | 0.9830 | 0.3008 | 0.5215 | 8.0931 |
| Valproic acid | HCC2185 | -1.8239 | 0.9298 | -2.4412 | -2.4374 | -2.9673 | 2.8680 | 0.0170 | 0.0587 | 7.6315 |
| Valproic acid | HCC3153 | -1.8239 | 0.9730 | -2.4393 | -2.4161 | -2.5695 | 3.0895 | 0.0747 | 0.1010 | 7.7687 |
| Valproic acid | LY2 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| Valproic acid | ZR75B | -1.8239 | 0.9475 | -2.5406 | -2.5406 | -2.7337 | 1.4670 | 0.0000 | 0.0816 | 7.1588 |
| Z-Leu-Leu-Norvalinal | MCF7 | -4.1759 | 0.9820 | -5.6629 | -5.6560 | -5.8182 | 1.8940 | 0.0143 | 0.0158 | 6.2138 |
| Z-Leu-Leu-Norvalinal | SK-BR-3 | -4.1759 | 0.9890 | -6.0449 | -6.0270 | -6.1340 | 3.0140 | 0.0574 | 0.0574 | 5.9343 |
| Z-Leu-Leu-Norvalinal | MDA-MB-231 | -4.1759 | 0.9916 | -6.0299 | -6.0271 | -6.0541 | 3.9990 | 0.0109 | 0.0109 | 5.9474 |
| Z-Leu-Leu-Norvalinal | AU565 | -4.1759 | 0.9822 | -6.2729 | -6.2668 | -6.3699 | 3.2500 | 0.0190 | 0.0190 | 5.4398 |
| Z-Leu-Leu-Norvalinal | BT-20 | -4.1759 | 0.9984 | -6.1669 | -6.1655 | -6.4118 | 3.2450 | 0.0036 | 0.0036 | 5.6428 |
| Z-Leu-Leu-Norvalinal | BT-474 | -4.1759 | 0.9775 | -5.7444 | -5.6398 | -6.2190 | 1.4895 | 0.1463 | 0.1567 | 6.5937 |
| Z-Leu-Leu-Norvalinal | BT-483 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| Z-Leu-Leu-Norvalinal | BT-549 | -4.1759 | 0.9881 | -6.4449 | -6.4452 | -6.5093 | 2.9590 | 0.0000 | 0.0000 | 5.0925 |
| Z-Leu-Leu-Norvalinal | CAMA-1 | -4.1759 | 0.9932 | -6.1179 | -6.1105 | -6.3269 | 2.5350 | 0.0220 | 0.0220 | 5.6478 |
| Z-Leu-Leu-Norvalinal | HCC1143 | -4.1759 | 0.9776 | -6.1579 | -6.1566 | -6.3208 | 1.6910 | 0.0020 | 0.0024 | 5.3934 |
| Z-Leu-Leu-Norvalinal | HCC1395 | -4.1759 | 0.7513 | -6.1219 | -6.0097 | -6.2038 | 3.9950 | 0.3221 | 0.3221 | 6.5143 |
| Z-Leu-Leu-Norvalinal | HCC1419 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| Z-Leu-Leu-Norvalinal | HCC1428 | -4.1759 | 0.9888 | -5.6669 | -5.4336 | -6.1560 | 3.1300 | 0.4069 | 0.4069 | 7.4502 |
| Z-Leu-Leu-Norvalinal | HCC1569 | -4.1759 | 0.9280 | -6.2469 | -6.1312 | -6.4100 | 1.3480 | 0.1512 | 0.1526 | 5.6524 |