Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Torkinib | MCF12A | -4.3010 | 0.9504 | -7.6850 | -7.0554 | -7.7564 | 0.3975 | 0.2189 | 0.2527 | 4.9015 |
| Torkinib | MX1 | -4.3010 | 0.9703 | -6.1530 | -6.1533 | -8.5843 | 0.6060 | 0.0000 | 0.0701 | 5.6358 |
| Torkinib | T47DKBLUC | -4.3010 | 0.9063 | -9.3870 | -5.1956 | -9.6065 | 0.4163 | 0.4910 | 0.4949 | 5.3140 |
| Torkinib | 600MPE | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| Torkinib | HCC2185 | -4.3010 | 0.9758 | -8.3570 | -7.4396 | -9.6944 | 0.4359 | 0.3010 | 0.3127 | 4.7229 |
| Torkinib | HCC3153 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| Torkinib | LY2 | -4.3010 | 0.9634 | -8.1970 | -6.7260 | -8.2157 | 0.4886 | 0.4044 | 0.4118 | 5.4572 |
| Torkinib | ZR75B | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| Valproic acid | MCF7 | -1.8239 | 0.9500 | -2.2909 | -2.2348 | -2.6402 | 1.7280 | 0.1000 | 0.2214 | 7.9772 |
| Valproic acid | SK-BR-3 | -1.8239 | 0.9461 | -2.8599 | -2.8600 | -3.1183 | 1.3620 | 0.0000 | 0.0373 | 6.5826 |
| Valproic acid | MDA-MB-231 | -1.8239 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | 9.0492 |
| Valproic acid | AU565 | -1.8239 | 0.9633 | -2.7437 | -2.7436 | -2.8960 | 1.9410 | 0.0000 | 0.0161 | 7.1314 |
| Valproic acid | BT-20 | -1.8239 | 0.8160 | -2.3127 | -2.0752 | -2.4689 | 3.2920 | 0.2469 | 0.2785 | 7.8380 |
| Valproic acid | BT-474 | -1.8239 | 0.9366 | -2.5820 | -2.5821 | -3.1409 | 1.3030 | 0.0000 | 0.1051 | 7.1024 |
| Valproic acid | BT-483 | -1.8239 | 0.9401 | -2.3275 | -2.3276 | -3.1245 | 1.1890 | 0.0000 | 0.2015 | 7.4905 |
| Valproic acid | BT-549 | -1.8239 | 0.9274 | -2.5216 | -2.5216 | -2.5784 | 1.7380 | 0.0000 | 0.0578 | 7.2743 |
| Valproic acid | CAMA-1 | -1.8239 | 0.9165 | -2.4408 | -2.4408 | -2.8440 | 1.5265 | 0.0000 | 0.1064 | 7.2908 |
| Valproic acid | HCC1143 | -1.8239 | 0.9582 | -2.4064 | -2.4064 | -2.6593 | 1.0470 | 0.0000 | 0.1971 | 7.5804 |
| Valproic acid | HCC1395 | -1.8239 | 0.7814 | -2.1405 | -2.1208 | -2.4907 | 1.5360 | 0.0412 | 0.2832 | 7.5542 |
| Valproic acid | HCC1419 | -1.8239 | 0.9033 | -2.4163 | -2.4163 | -3.0491 | 1.5870 | 0.0000 | 0.1030 | 7.3187 |
| Valproic acid | HCC1428 | -1.8239 | 0.9764 | -2.8929 | -2.8884 | -3.1603 | 2.1525 | 0.0108 | 0.0159 | 6.8314 |
| Valproic acid | HCC1569 | -1.8239 | 0.9683 | -2.4651 | -2.4650 | -2.7894 | 1.2505 | 0.0000 | 0.1406 | 7.3888 |
| Valproic acid | HCC1806 | -1.8239 | 0.8063 | -2.5025 | -2.5025 | -2.6758 | 1.0380 | 0.0000 | 0.1649 | 6.7918 |
| Valproic acid | HCC1937 | -1.8239 | 0.9334 | -2.3849 | -2.3849 | -2.5667 | 2.0470 | 0.0000 | 0.0664 | 7.6838 |
| Valproic acid | HCC1954 | -1.8239 | 0.9498 | -2.3552 | -2.3553 | -2.5204 | 1.6000 | 0.0000 | 0.1237 | 7.8633 |