Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Vorinostat | ZR-75-1 | -1.7282 | 0.9534 | -3.5772 | -3.3587 | -3.8290 | 1.1575 | 0.2192 | 0.2249 | 6.4985 |
| Vorinostat | 184B5 | -1.7282 | 0.9745 | -3.3062 | -3.3059 | -3.8772 | 0.5986 | 0.0000 | 0.1044 | 6.0817 |
| Vorinostat | HCC1187 | -1.7282 | 0.9846 | -4.4602 | -4.4493 | -4.7289 | 2.4440 | 0.0197 | 0.0197 | 4.9035 |
| Vorinostat | MCF 10A | -1.7282 | 0.9823 | -3.7122 | -3.6778 | -3.7353 | 1.2590 | 0.0489 | 0.0511 | 5.9794 |
| Vorinostat | MCF 10F | -1.7282 | 0.9436 | -2.9172 | -2.8810 | -3.1133 | 1.9120 | 0.0743 | 0.0792 | 7.3687 |
| Vorinostat | SUM1315MO2 | -1.7282 | 0.9799 | -3.4057 | -3.3764 | -3.7996 | 1.0474 | 0.0309 | 0.0520 | 6.1973 |
| Vorinostat | SUM149PT | -1.7282 | 0.9920 | -3.9272 | -3.9268 | -4.0666 | 1.5390 | 0.0000 | 0.0004 | 5.2120 |
| Vorinostat | SUM159PT | -1.7282 | 0.9790 | -3.8962 | -3.8956 | -3.9602 | 1.2370 | 0.0006 | 0.0027 | 5.4695 |
| Vorinostat | SUM185PE | -1.7282 | 0.9753 | -3.6222 | -3.6227 | -4.3780 | 0.8822 | 0.0000 | 0.0209 | 5.7487 |
| Vorinostat | SUM225CWN | -1.7282 | 0.9344 | -3.5607 | -3.5428 | -3.8546 | 1.5760 | 0.0311 | 0.0331 | 5.9070 |
| Vorinostat | SUM229PE | -1.7282 | 0.9334 | -3.7762 | -3.7552 | -4.0367 | 1.7750 | 0.0395 | 0.0409 | 5.6922 |
| Vorinostat | SUM52PE | -1.7282 | 0.8570 | -4.3732 | -4.3733 | -4.8038 | 0.8273 | 0.0000 | 0.0064 | 4.5057 |
| Vorinostat | 184A1 | -1.7282 | 0.9624 | -3.5347 | -3.4273 | -3.8929 | 0.7632 | 0.0877 | 0.1295 | 6.3101 |
| Vorinostat | MCF12A | -1.7282 | 0.9795 | -3.7242 | -3.6907 | -3.8270 | 1.2010 | 0.0449 | 0.0487 | 5.7846 |
| Vorinostat | MX1 | -1.7282 | 0.9771 | -3.5082 | -3.4798 | -4.0465 | 1.0530 | 0.0329 | 0.0456 | 6.2484 |
| Vorinostat | T47DKBLUC | -1.7282 | 0.9866 | -3.8082 | -3.8045 | -4.0261 | 1.8440 | 0.0083 | 0.0103 | 5.4855 |
| Vorinostat | 600MPE | -1.7282 | 0.9619 | -3.6012 | -3.6011 | -4.2072 | 0.9318 | 0.0000 | 0.0192 | 5.5309 |
| Vorinostat | HCC2185 | -1.7282 | 0.9833 | -3.8252 | -3.8251 | -4.2670 | 1.8130 | 0.0006 | 0.0007 | 5.3513 |
| Vorinostat | HCC3153 | -1.7282 | 0.9812 | -3.5822 | -3.4995 | -3.8063 | 1.3620 | 0.1365 | 0.1391 | 6.2670 |
| Vorinostat | LY2 | -1.7282 | 0.9878 | -3.6142 | -3.6088 | -3.7643 | 2.0960 | 0.0130 | 0.0131 | 5.9611 |
| Vorinostat | ZR75B | -1.7282 | 0.9676 | -3.9042 | -3.8367 | -4.0697 | 1.2250 | 0.0871 | 0.0891 | 5.5659 |
| XRP44X | MCF7 | -3.8761 | 0.8247 | -6.4121 | -3.8761 | -6.3476 | 3.9850 | 0.5337 | 0.5337 | 7.0612 |
| XRP44X | SK-BR-3 | -3.8761 | 0.9331 | -5.6931 | -5.5513 | -5.6921 | 3.9970 | 0.3648 | 0.3648 | 6.7927 |
| XRP44X | MDA-MB-231 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| XRP44X | AU565 | -3.8761 | 0.9662 | -6.4121 | -6.3928 | -6.4753 | 3.1710 | 0.0670 | 0.0670 | 4.9351 |