Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Nutlin 3a | SUM1315MO2 | -4.1759 | 0.8622 | -4.4465 | -4.4465 | -4.7517 | 1.6350 | 0.0000 | 0.2503 | 8.0487 |
| Nutlin 3a | SUM149PT | -4.1759 | 0.9629 | -4.5118 | -4.5118 | -4.5033 | 2.1610 | 0.0000 | 0.1582 | 7.9705 |
| Nutlin 3a | SUM159PT | -4.1759 | 0.8835 | -4.6891 | -4.6651 | -4.6895 | 3.9990 | 0.0994 | 0.1073 | 8.1265 |
| Nutlin 3a | SUM185PE | -4.1759 | 0.8178 | -4.2760 | -4.2760 | -4.5962 | 1.5670 | 0.0000 | 0.4107 | 8.0758 |
| Nutlin 3a | SUM225CWN | -4.1759 | 0.9474 | -4.5507 | -4.5506 | -4.6605 | 2.6905 | 0.0000 | 0.1014 | 7.8593 |
| Nutlin 3a | SUM229PE | -4.1759 | 0.9147 | -4.5464 | -4.5464 | -4.6310 | 2.5740 | 0.0000 | 0.1299 | 7.6274 |
| Nutlin 3a | SUM52PE | -4.1759 | 0.9496 | -4.5383 | -4.5383 | -4.6385 | 2.0180 | 0.0000 | 0.1566 | 7.4002 |
| Nutlin 3a | 184A1 | -4.1759 | 0.9227 | -5.0572 | -5.0573 | -5.4041 | 0.8567 | 0.0000 | 0.1499 | 7.1644 |
| Nutlin 3a | MCF12A | -4.1759 | 0.9692 | -5.8674 | -5.6610 | -5.8686 | 1.0120 | 0.1898 | 0.2059 | 6.5847 |
| Nutlin 3a | MX1 | -4.1759 | 0.9024 | -4.4813 | -4.4813 | -4.6732 | 2.3140 | 0.0000 | 0.1642 | 7.6906 |
| Nutlin 3a | T47DKBLUC | -4.1759 | 0.7386 | -4.1099 | -4.2340 | -4.4720 | 1.1655 | 0.0000 | 0.5297 | 8.4073 |
| Nutlin 3a | 600MPE | -4.1759 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | 8.3194 |
| Nutlin 3a | HCC2185 | -4.1759 | 0.7492 | -4.2261 | -4.2261 | -4.7421 | 1.5410 | 0.0000 | 0.4567 | 8.2851 |
| Nutlin 3a | HCC3153 | -4.1759 | 0.8559 | -4.3749 | -4.2747 | -4.4610 | 2.2560 | 0.0001 | 0.4083 | 8.0622 |
| Nutlin 3a | LY2 | -4.1759 | 0.8997 | -5.0132 | -5.0133 | -5.3139 | 1.3200 | 0.0000 | 0.0727 | 7.9411 |
| Nutlin 3a | ZR75B | -4.1759 | 0.9268 | -5.7519 | -5.3211 | -5.7356 | 1.0260 | 0.3194 | 0.3354 | 6.9106 |
| Oxaliplatin | MCF7 | -3.2013 | 0.9460 | -4.3493 | -4.3497 | -5.3091 | 0.6103 | 0.0000 | 0.1642 | 6.8281 |
| Oxaliplatin | SK-BR-3 | -3.2013 | 0.9733 | -5.1808 | -5.1696 | -5.5613 | 1.1515 | 0.0135 | 0.0191 | 5.9060 |
| Oxaliplatin | MDA-MB-231 | -3.2013 | 0.9406 | -4.4493 | -4.4230 | -4.5405 | 0.6934 | 0.0624 | 0.0953 | 6.8351 |
| Oxaliplatin | AU565 | -3.2013 | 0.9693 | -5.2018 | -5.2000 | -5.5642 | 1.1945 | 0.0027 | 0.0070 | 5.5616 |
| Oxaliplatin | BT-20 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| Oxaliplatin | BT-474 | -3.2013 | 0.9355 | -4.1291 | -4.1291 | -4.7458 | 0.9971 | 0.0000 | 0.1062 | 6.9764 |
| Oxaliplatin | BT-483 | -3.2013 | 0.8979 | -4.2543 | -3.6987 | -4.5122 | 1.8080 | 0.4506 | 0.4574 | 8.0095 |
| Oxaliplatin | BT-549 | -3.2013 | 0.9795 | -5.6888 | -5.6724 | -5.8497 | 0.9202 | 0.0000 | 0.0056 | 5.0972 |
| Oxaliplatin | CAMA-1 | -3.2013 | 0.9502 | -4.4623 | -4.4628 | -5.1725 | 0.8741 | 0.0000 | 0.0732 | 6.4223 |