Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Fascaplysin | HCC1954 | -4.4776 | 0.9839 | -6.4836 | -6.4839 | -6.5772 | 2.5395 | 0.0000 | 0.0000 | 5.5274 |
| Omipalisib | HCC1143 | -4.4776 | 0.9819 | -7.3286 | -7.1069 | -7.4557 | 0.8936 | 0.1828 | 0.1851 | 5.2906 |
| Omipalisib | HCC1395 | -4.4776 | 0.9674 | -7.0311 | -6.6125 | -7.3086 | 0.9230 | 0.2903 | 0.2936 | 6.1517 |
| Omipalisib | HCC1419 | -4.4776 | 0.9393 | -7.8176 | -7.3177 | -8.7550 | 0.7216 | 0.2822 | 0.2850 | 5.2439 |
| Omipalisib | HCC1428 | -4.4776 | 0.9389 | -7.0436 | -6.6504 | -7.5424 | 0.8643 | 0.2607 | 0.2826 | 5.9711 |
| Omipalisib | HCC1569 | -4.4776 | 0.9648 | -7.7576 | -7.5276 | -7.7975 | 1.2645 | 0.2412 | 0.2413 | 5.1165 |
| Omipalisib | HCC1806 | -4.4776 | 0.9844 | -7.2646 | -7.1920 | -7.5727 | 0.6333 | 0.0504 | 0.0665 | 4.7285 |
| Omipalisib | HCC1937 | -4.4776 | 0.9796 | -7.3266 | -6.9723 | -7.5849 | 0.6869 | 0.2146 | 0.2232 | 5.4591 |
| Omipalisib | HCC1954 | -4.4776 | 0.9507 | -7.8256 | -7.7807 | -8.1463 | 1.1974 | 0.0450 | 0.0466 | 3.8101 |
| Omipalisib | HCC202 | -4.4776 | 0.9925 | -8.0786 | -8.0068 | -8.9423 | 0.9984 | 0.0758 | 0.0760 | 3.7918 |
| Omipalisib | HCC38 | -4.4776 | 0.9805 | -7.1526 | -7.0798 | -7.6187 | 0.9370 | 0.0549 | 0.0595 | 4.8099 |
| Omipalisib | HCC70 | -4.4776 | 0.9751 | -7.5826 | -7.5358 | -8.1178 | 0.8673 | 0.0444 | 0.0464 | 4.2358 |
| Omipalisib | Hs 578T | -4.4776 | 0.9865 | -7.1286 | -6.9171 | -7.1638 | 0.7774 | 0.1579 | 0.1652 | 6.6007 |
| Gefitinib | HCC1143 | -4.4776 | 0.7888 | -4.8484 | -4.5649 | -5.0588 | 1.0312 | 0.2441 | 0.4962 | 8.4272 |
| Omipalisib | MDA-MB-134-VI | -4.4776 | 0.9885 | -7.2176 | -7.2177 | -7.9713 | 0.7442 | 0.0000 | 0.0092 | 4.4619 |
| Omipalisib | MDA-MB-157 | -4.4776 | 0.9549 | -6.0816 | -5.4106 | -6.5395 | 0.6444 | 0.2980 | 0.3850 | 6.9857 |
| Fascaplysin | HCC2185 | -4.4776 | 0.9710 | -6.4916 | -6.4913 | -6.8490 | 1.8110 | 0.0000 | 0.0002 | 5.3366 |
| Ispinesib | CAMA-1 | -4.4776 | 0.9764 | -7.5631 | -7.5265 | -7.6633 | 3.6505 | 0.1281 | 0.1281 | 4.6158 |
| Ixabepilone | AU565 | -4.4045 | 0.9793 | -8.3790 | -8.3705 | -8.4523 | 3.0590 | 0.0256 | 0.0256 | 2.9694 |
| Ixabepilone | MDA-MB-231 | -4.4045 | 0.9286 | -9.2455 | -9.2112 | -9.2591 | 1.4930 | 0.1324 | 0.1324 | 2.3981 |
| Ixabepilone | SK-BR-3 | -4.4045 | 0.9589 | -7.9180 | -7.8877 | -7.9767 | 3.4980 | 0.1086 | 0.1086 | 4.0217 |
| Ixabepilone | MCF7 | -4.4045 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | 4.1086 |
| Ixabepilone | HCC3153 | -4.4045 | 0.9494 | -8.0295 | -7.8600 | -8.2162 | 1.7260 | 0.1971 | 0.1971 | 4.3942 |
| Ixabepilone | HCC2185 | -4.4045 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | 6.5816 |
| Ixabepilone | LY2 | -4.4045 | 0.9574 | -8.1385 | -8.0814 | -8.2570 | 2.0620 | 0.1187 | 0.1187 | 3.9722 |