Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| TCS 2312 | MDA-MB-157 | -4.4776 | 0.9847 | -6.7216 | -6.7088 | -6.8055 | 4.0000 | 0.0542 | 0.0542 | 5.6916 |
| LBH589 | SUM52PE | -4.4776 | 0.9673 | -6.7156 | -6.7079 | -6.8578 | 2.8885 | 0.0217 | 0.0218 | 5.4062 |
| Bortezomib | MDA-MB-436 | -3.7773 | 0.9927 | -6.7283 | -6.7046 | -6.8773 | 1.6020 | 0.0428 | 0.0428 | 4.4744 |
| MG-132 | MDA-MB-436 | -4.1759 | 0.9796 | -6.7139 | -6.7022 | -6.8806 | 2.8220 | 0.0366 | 0.0366 | 4.9542 |
| Pevonedistat | MCF12A | -4.1759 | 0.9837 | -7.0024 | -6.6975 | -7.0920 | 0.8586 | 0.2204 | 0.2236 | 5.3896 |
| LBH589 | MDA-MB-134-VI | -4.4776 | 0.9583 | -6.8901 | -6.6939 | -7.1038 | 1.6615 | 0.2638 | 0.2638 | 6.0309 |
| Bortezomib | BT-474 | -3.7773 | 0.9481 | -6.8908 | -6.6851 | -7.4937 | 0.8324 | 0.1634 | 0.1661 | 4.9490 |
| LBH589 | SUM185PE | -4.4776 | 0.9596 | -6.7176 | -6.6847 | -7.1017 | 1.1760 | 0.0423 | 0.0446 | 5.4740 |
| LBH589 | HCC1187 | -4.4776 | 0.9872 | -6.6896 | -6.6822 | -6.7678 | 4.0000 | 0.0320 | 0.0320 | 5.6436 |
| MG-132 | Hs 578T | -4.1759 | 0.9796 | -6.6819 | -6.6802 | -6.7357 | 3.3020 | 0.0063 | 0.0063 | 4.8941 |
| LBH589 | T47DKBLUC | -4.4776 | 0.9929 | -6.6796 | -6.6784 | -6.8953 | 1.7730 | 0.0028 | 0.0030 | 5.3574 |
| Oxamflatin | HCC38 | -4.1759 | 0.9761 | -6.6779 | -6.6763 | -6.8320 | 1.3210 | 0.0030 | 0.0035 | 4.7352 |
| MG-132 | HCC3153 | -4.1759 | 0.8532 | -6.7009 | -6.6745 | -6.7822 | 4.0000 | 0.1086 | 0.1086 | 5.3325 |
| MG-132 | HCC1954 | -4.1759 | 0.9783 | -6.6929 | -6.6734 | -6.7443 | 3.9980 | 0.0814 | 0.0814 | 5.2452 |
| Bortezomib | MCF7 | -3.7773 | 0.9589 | -6.7713 | -6.6724 | -7.0551 | 1.3098 | 0.1231 | 0.1248 | 4.8840 |
| GSK923295 | MDA-MB-134-VI | -4.4776 | 0.9558 | -6.9366 | -6.6702 | -6.9826 | 3.9770 | 0.4617 | 0.4617 | 7.7426 |
| Doxorubicin | Hs 578T | -6.2596 | 0.8971 | -6.6679 | -6.6679 | -6.9052 | 0.6556 | 0.0000 | 0.3499 | 7.4580 |
| Trametinib | MDA-MB-134-VI | -4.7773 | 0.9541 | -7.6033 | -6.6651 | -8.0082 | 0.9934 | 0.4416 | 0.4425 | 6.4887 |
| Epirubicin | BT-549 | -3.7645 | 0.9551 | -6.6635 | -6.6622 | -6.7433 | 1.6005 | 0.0026 | 0.0027 | 4.2378 |
| Doxorubicin | MDA-MB-453 | -6.2596 | 0.8523 | -6.6610 | -6.6611 | -6.9194 | 2.4350 | 0.0000 | 0.0953 | 7.4383 |
| Ispinesib | MCF7 | -4.4776 | 0.8900 | -6.6601 | -6.6600 | -7.3871 | 0.4538 | 0.0000 | 0.0930 | 5.3114 |
| 17-AAG | HCC1569 | -4.0000 | 0.9600 | -6.7970 | -6.6593 | -6.8748 | 2.5205 | 0.2149 | 0.2154 | 5.4975 |
| MG-132 | SUM225CWN | -4.1759 | 0.9022 | -6.8229 | -6.6578 | -7.0509 | 1.5530 | 0.2088 | 0.2095 | 5.6815 |
| Pevonedistat | AU565 | -4.1759 | 0.9700 | -6.7649 | -6.6571 | -6.8026 | 2.3630 | 0.2215 | 0.2215 | 5.6749 |
| MG-132 | MDA-MB-134-VI | -4.1759 | 0.8274 | -6.6899 | -6.6551 | -6.7627 | 4.0000 | 0.1360 | 0.1360 | 5.3201 |